Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia
Objective To investigate the value and safety of microdissection testicular sperm extraction (MD-TESE) for patients with non-obstructive azoospermia (NOA). Methods A retrospective analysis study of 176 NOA patients diagnosed in our center from July 1, 2017 to March 15, 2022. According to sperm retri...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Army Medical University
2023-02-01
|
| Series: | 陆军军医大学学报 |
| Subjects: | |
| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202208194.htm |
| _version_ | 1811166186579165184 |
|---|---|
| author | HONG Wei WANG Ying ZHU Lin LIU Junxuan ZENG Jitao |
| author_facet | HONG Wei WANG Ying ZHU Lin LIU Junxuan ZENG Jitao |
| author_sort | HONG Wei |
| collection | DOAJ |
| description | Objective To investigate the value and safety of microdissection testicular sperm extraction (MD-TESE) for patients with non-obstructive azoospermia (NOA). Methods A retrospective analysis study of 176 NOA patients diagnosed in our center from July 1, 2017 to March 15, 2022. According to sperm retrieval methods, they were divided into MD-TESE group and testicular sperm aspiration (TESA) group. The time of procedure, intra-operative bleeding, surgical complications (such as hematoma), sperm retrieval rate (SRR) and clinical outcome of in vitro fertilization were compared between the 2 groups. Results There were no significant differences between the 2 groups in age, body mass index (BMI), testicular volume, and levels of testosterone (T), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) (P>0.05). The MD-TESE group had obviously longer operation time (P < 0.001) and lower incidence of testicular hematoma rate than the TESA group. No infections were observed in either group. SRR was significantly higher in MD-TESE group than the TESA group. When the obtained sperms were used in intracytoplasmic sperm injection (ICSI), no obvious differences were seen in the fertilization rate, cleavage rate, and clinical pregnancy rate between the MD-TESE group and TESA group (65.1% vs 58.3%, 93.9% vs 71.4%, 50.0% vs 50.0%). Conclusion MD-TESE is a safe and effective method for sperm retrieval in NOA patients, especially in those with cryptorchidism, viral orchitis and Y-chromosome AZFc microdeletions.
|
| first_indexed | 2024-04-10T15:48:34Z |
| format | Article |
| id | doaj.art-6bc90032cff54062978f96cbf3094b1f |
| institution | Directory Open Access Journal |
| issn | 2097-0927 |
| language | zho |
| last_indexed | 2024-04-10T15:48:34Z |
| publishDate | 2023-02-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj.art-6bc90032cff54062978f96cbf3094b1f2023-02-12T02:30:13ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272023-02-0145325125610.16016/j.2097-0927.202208194Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermiaHONG Wei0WANG Ying1ZHU Lin2LIU Junxuan3ZENG Jitao4Center for Reproductive Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaCenter for Reproductive Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaCenter for Reproductive Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaCenter for Reproductive Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaCenter for Reproductive Medicine, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaObjective To investigate the value and safety of microdissection testicular sperm extraction (MD-TESE) for patients with non-obstructive azoospermia (NOA). Methods A retrospective analysis study of 176 NOA patients diagnosed in our center from July 1, 2017 to March 15, 2022. According to sperm retrieval methods, they were divided into MD-TESE group and testicular sperm aspiration (TESA) group. The time of procedure, intra-operative bleeding, surgical complications (such as hematoma), sperm retrieval rate (SRR) and clinical outcome of in vitro fertilization were compared between the 2 groups. Results There were no significant differences between the 2 groups in age, body mass index (BMI), testicular volume, and levels of testosterone (T), luteinizing hormone (LH), anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) (P>0.05). The MD-TESE group had obviously longer operation time (P < 0.001) and lower incidence of testicular hematoma rate than the TESA group. No infections were observed in either group. SRR was significantly higher in MD-TESE group than the TESA group. When the obtained sperms were used in intracytoplasmic sperm injection (ICSI), no obvious differences were seen in the fertilization rate, cleavage rate, and clinical pregnancy rate between the MD-TESE group and TESA group (65.1% vs 58.3%, 93.9% vs 71.4%, 50.0% vs 50.0%). Conclusion MD-TESE is a safe and effective method for sperm retrieval in NOA patients, especially in those with cryptorchidism, viral orchitis and Y-chromosome AZFc microdeletions. http://aammt.tmmu.edu.cn/Upload/rhtml/202208194.htmnon-obstructive azoospermiamicrodissection testicular sperm extractiontesticular sperm extractionsperm retrieval ratesurgical complications |
| spellingShingle | HONG Wei WANG Ying ZHU Lin LIU Junxuan ZENG Jitao Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia 陆军军医大学学报 non-obstructive azoospermia microdissection testicular sperm extraction testicular sperm extraction sperm retrieval rate surgical complications |
| title | Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia |
| title_full | Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia |
| title_fullStr | Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia |
| title_full_unstemmed | Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia |
| title_short | Application of microdissection testicular sperm extraction for patients with non-obstructive azoospermia |
| title_sort | application of microdissection testicular sperm extraction for patients with non obstructive azoospermia |
| topic | non-obstructive azoospermia microdissection testicular sperm extraction testicular sperm extraction sperm retrieval rate surgical complications |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202208194.htm |
| work_keys_str_mv | AT hongwei applicationofmicrodissectiontesticularspermextractionforpatientswithnonobstructiveazoospermia AT wangying applicationofmicrodissectiontesticularspermextractionforpatientswithnonobstructiveazoospermia AT zhulin applicationofmicrodissectiontesticularspermextractionforpatientswithnonobstructiveazoospermia AT liujunxuan applicationofmicrodissectiontesticularspermextractionforpatientswithnonobstructiveazoospermia AT zengjitao applicationofmicrodissectiontesticularspermextractionforpatientswithnonobstructiveazoospermia |