Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis
Osteoporosis is characterized by low bone mass and increased bone fragility. Numerous studies have suggested that inflammation contributes to its pathogenesis. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, noninvasive biomarkers that can reflect the infl...
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/12/2968 |
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| author | Yu-Cheng Liu Tzu-I Yang Shu-Wei Huang Yi-Jie Kuo Yu-Pin Chen |
| author_facet | Yu-Cheng Liu Tzu-I Yang Shu-Wei Huang Yi-Jie Kuo Yu-Pin Chen |
| author_sort | Yu-Cheng Liu |
| collection | DOAJ |
| description | Osteoporosis is characterized by low bone mass and increased bone fragility. Numerous studies have suggested that inflammation contributes to its pathogenesis. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, noninvasive biomarkers that can reflect the inflammation status on human body. However, evidence on their associations with osteoporosis remains scant. The PubMed, Embase, and Cochrane Library databases were searched for relevant studies from their inception to April 2022. Observational studies providing complete NLR or PLR data in both the osteoporosis and normal bone mineral density (BMD) groups were included. Studies involving individuals at risk of secondary osteoporosis or restricted to a certain disease population were excluded. The main outcome was the associations of NLR and PLR with osteoporosis. Between-group differences were measured using mean differences (MDs) and 95% confidence intervals (CIs). In our analysis, both NLR and PLR were significantly higher in the osteoporosis group (MD = 0.494, 95% CI: 0.339–0.649, <i>p</i> < 0.0001; MD = 23.33, 95% CI: 4.809–41.850, <i>p</i> = 0.014, respectively) than in the normal BMD group. NLR was significantly higher in postmenopausal women with osteoporosis (MD = 0.432, 95% CI: 0.309–0.544, <i>p</i> < 0.0001). Our findings suggest the associations of NLR and PLR with osteoporosis. NLR and PLR constitute potential targets in osteoporosis screening. |
| first_indexed | 2024-03-09T17:08:21Z |
| format | Article |
| id | doaj.art-6bc98971355b4ecda81ec8e5bce5ea52 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T17:08:21Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-6bc98971355b4ecda81ec8e5bce5ea522023-11-24T14:16:22ZengMDPI AGDiagnostics2075-44182022-11-011212296810.3390/diagnostics12122968Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-AnalysisYu-Cheng Liu0Tzu-I Yang1Shu-Wei Huang2Yi-Jie Kuo3Yu-Pin Chen4College of Medicine, Taipei Medical University, Taipei 110301, TaiwanDepartment of General Medicine, Changhua Christian Hospital, Changhua 500209, TaiwanDepartment of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei 110301, TaiwanDepartment of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei 110301, TaiwanDepartment of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei 110301, TaiwanOsteoporosis is characterized by low bone mass and increased bone fragility. Numerous studies have suggested that inflammation contributes to its pathogenesis. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple, noninvasive biomarkers that can reflect the inflammation status on human body. However, evidence on their associations with osteoporosis remains scant. The PubMed, Embase, and Cochrane Library databases were searched for relevant studies from their inception to April 2022. Observational studies providing complete NLR or PLR data in both the osteoporosis and normal bone mineral density (BMD) groups were included. Studies involving individuals at risk of secondary osteoporosis or restricted to a certain disease population were excluded. The main outcome was the associations of NLR and PLR with osteoporosis. Between-group differences were measured using mean differences (MDs) and 95% confidence intervals (CIs). In our analysis, both NLR and PLR were significantly higher in the osteoporosis group (MD = 0.494, 95% CI: 0.339–0.649, <i>p</i> < 0.0001; MD = 23.33, 95% CI: 4.809–41.850, <i>p</i> = 0.014, respectively) than in the normal BMD group. NLR was significantly higher in postmenopausal women with osteoporosis (MD = 0.432, 95% CI: 0.309–0.544, <i>p</i> < 0.0001). Our findings suggest the associations of NLR and PLR with osteoporosis. NLR and PLR constitute potential targets in osteoporosis screening.https://www.mdpi.com/2075-4418/12/12/2968neutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratioosteoporosisbone mineral density |
| spellingShingle | Yu-Cheng Liu Tzu-I Yang Shu-Wei Huang Yi-Jie Kuo Yu-Pin Chen Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis Diagnostics neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio osteoporosis bone mineral density |
| title | Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis |
| title_full | Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis |
| title_fullStr | Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis |
| title_full_unstemmed | Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis |
| title_short | Associations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Osteoporosis: A Meta-Analysis |
| title_sort | associations of the neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with osteoporosis a meta analysis |
| topic | neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio osteoporosis bone mineral density |
| url | https://www.mdpi.com/2075-4418/12/12/2968 |
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