Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg
The aim of the analysis was to describe the results of administration of pan-genotype antiviral therapy (glecaprevir / pibrentasvir, GLE / PIB) in real-world setting in three clinical centers in St. Petersburg within the city program for the treatment of chronic hepatitis C. Materials and methods....
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2023-01-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/1427 |
| _version_ | 1797702564597202944 |
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| author | D. A. Gusev K. V. Zhdanov K. V. Kozlov T. N. Vinogradova M. Yu. Kopot V. S. Sukachev S. S. Zhabrov S. N. Kizhlo S. Yu. Romanova V. B. Musatov N. V. Tyurenkova Yu. A. Vlasova E. Yu. Kolpashchikova P. N. Fedorov P. V. Minin T. S. Korneeva |
| author_facet | D. A. Gusev K. V. Zhdanov K. V. Kozlov T. N. Vinogradova M. Yu. Kopot V. S. Sukachev S. S. Zhabrov S. N. Kizhlo S. Yu. Romanova V. B. Musatov N. V. Tyurenkova Yu. A. Vlasova E. Yu. Kolpashchikova P. N. Fedorov P. V. Minin T. S. Korneeva |
| author_sort | D. A. Gusev |
| collection | DOAJ |
| description | The aim of the analysis was to describe the results of administration of pan-genotype antiviral therapy (glecaprevir / pibrentasvir, GLE / PIB) in real-world setting in three clinical centers in St. Petersburg within the city program for the treatment of chronic hepatitis C. Materials and methods. A retrospective analysis of the GLE / PIB usage of in the period from 2019 to 2022 within the city program for the treatment of chronic hepatitis C in St. Petersburg was carried out. Results. The analysis included 464 patients treated in three clinical centers of St. Petersburg: St. Petersburg State Medical Institution “Clinical Infectious Diseases Hospital named after S. P. Botkin”, St. Petersburg State Medical Institution “Center for the Prevention and Control of AIDS and Infectious Diseases” and the Clinic of Infectious Diseases of the Military Medical Academy named after S. M.Kirov”. Overall 452 out of 464 patients (97 %) achieved SVR12. According to the duration of treatment, SVR12 rates were the following: 8 weeks – 97.7 % (419 / 429), 12 weeks – 92.9 % (26 / 28) and 16 weeks – 100 % (7 / 7). The effectiveness according to fibrosis stage was as follows: F0 – 97 % (142 / 146), F1 – 100 % (74 / 74), F2 – 100 % (59 / 59), F3 – 98 % (57 / 58), F4 (CP-A, B) – 94 % (118 / 125). SVR12 according to HCV genotypes and subtypes was the following: genotype 1b – 100 % (63 / 63), genotype 1a – 91 % (21 / 23), genotype 1 unspecified – 100 % (23 / 23), genotype 2 – 98 % (50 / 51), genotype 3 – 97 % (292 / 301). In patients with an indeterminate genotype, the efficacy was 100 % (7 / 7). Antiviral therapy was well tolerated, there were no cases of discontinuation of therapy, as well as cases of the development of serious adverse events. Conclusion. GLE / PIB has demonstrated high effectiveness in the real-world setting in patients infected with prevalent genotypes of HCV, including those with genotype 3 and compensated liver cirrhosis. The results of our analysis fully correspond to the data obtained earlier in clinical trials andreal-world setting. |
| first_indexed | 2024-03-12T04:52:54Z |
| format | Article |
| id | doaj.art-6bca810fbc6e4594b9f661b807d84ac9 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T04:52:54Z |
| publishDate | 2023-01-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-6bca810fbc6e4594b9f661b807d84ac92023-09-03T09:18:33ZrusJournal InfectologyЖурнал инфектологии2072-67322023-01-01145606810.22625/2072-6732-2022-14-5-60-681039Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. PetersburgD. A. Gusev0K. V. Zhdanov1K. V. Kozlov2T. N. Vinogradova3M. Yu. Kopot4V. S. Sukachev5S. S. Zhabrov6S. N. Kizhlo7S. Yu. Romanova8V. B. Musatov9N. V. Tyurenkova10Yu. A. Vlasova11E. Yu. Kolpashchikova12P. N. Fedorov13P. V. Minin14T. S. Korneeva15Клиническая инфекционная больница им. С. П. БоткинаВоенно-медицинская академия им. С. М. Кирова; МО РФ; РАНВоенно-медицинская академия им. С. М. КироваЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиВоенно-медицинская академия им. С. М. КироваВоенно-медицинская академия им. С. М. КироваВоенно-медицинская академия им. С. М. КироваЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиКлиническая инфекционная больница им. С. П. БоткинаКлиническая инфекционная больница им. С. П. БоткинаКлиническая инфекционная больница им. С. П. БоткинаЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиThe aim of the analysis was to describe the results of administration of pan-genotype antiviral therapy (glecaprevir / pibrentasvir, GLE / PIB) in real-world setting in three clinical centers in St. Petersburg within the city program for the treatment of chronic hepatitis C. Materials and methods. A retrospective analysis of the GLE / PIB usage of in the period from 2019 to 2022 within the city program for the treatment of chronic hepatitis C in St. Petersburg was carried out. Results. The analysis included 464 patients treated in three clinical centers of St. Petersburg: St. Petersburg State Medical Institution “Clinical Infectious Diseases Hospital named after S. P. Botkin”, St. Petersburg State Medical Institution “Center for the Prevention and Control of AIDS and Infectious Diseases” and the Clinic of Infectious Diseases of the Military Medical Academy named after S. M.Kirov”. Overall 452 out of 464 patients (97 %) achieved SVR12. According to the duration of treatment, SVR12 rates were the following: 8 weeks – 97.7 % (419 / 429), 12 weeks – 92.9 % (26 / 28) and 16 weeks – 100 % (7 / 7). The effectiveness according to fibrosis stage was as follows: F0 – 97 % (142 / 146), F1 – 100 % (74 / 74), F2 – 100 % (59 / 59), F3 – 98 % (57 / 58), F4 (CP-A, B) – 94 % (118 / 125). SVR12 according to HCV genotypes and subtypes was the following: genotype 1b – 100 % (63 / 63), genotype 1a – 91 % (21 / 23), genotype 1 unspecified – 100 % (23 / 23), genotype 2 – 98 % (50 / 51), genotype 3 – 97 % (292 / 301). In patients with an indeterminate genotype, the efficacy was 100 % (7 / 7). Antiviral therapy was well tolerated, there were no cases of discontinuation of therapy, as well as cases of the development of serious adverse events. Conclusion. GLE / PIB has demonstrated high effectiveness in the real-world setting in patients infected with prevalent genotypes of HCV, including those with genotype 3 and compensated liver cirrhosis. The results of our analysis fully correspond to the data obtained earlier in clinical trials andreal-world setting.https://journal.niidi.ru/jofin/article/view/1427хронический гепатит сглекапревир / пибрентасвирпангенотипныйреальная клиническая практика |
| spellingShingle | D. A. Gusev K. V. Zhdanov K. V. Kozlov T. N. Vinogradova M. Yu. Kopot V. S. Sukachev S. S. Zhabrov S. N. Kizhlo S. Yu. Romanova V. B. Musatov N. V. Tyurenkova Yu. A. Vlasova E. Yu. Kolpashchikova P. N. Fedorov P. V. Minin T. S. Korneeva Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg Журнал инфектологии хронический гепатит с глекапревир / пибрентасвир пангенотипный реальная клиническая практика |
| title | Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg |
| title_full | Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg |
| title_fullStr | Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg |
| title_full_unstemmed | Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg |
| title_short | Real-world effectiveness and safety of pan-genotypic antiviral therapy for chronic HCV-infection: data from three clinical centers in St. Petersburg |
| title_sort | real world effectiveness and safety of pan genotypic antiviral therapy for chronic hcv infection data from three clinical centers in st petersburg |
| topic | хронический гепатит с глекапревир / пибрентасвир пангенотипный реальная клиническая практика |
| url | https://journal.niidi.ru/jofin/article/view/1427 |
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