Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure

Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure

The archetypal store-operated Ca2+ channels (SOCs), Orai1, which are stimulated by the endo/sarcoplasmic reticulum (ER/SR) Ca2+ sensor stromal interaction molecule 1 (STIM1) upon Ca2+ store depletion is traditionally viewed as instrumental for the function of non-excitable cells. In the recent years...

Full description

Bibliographic Details
Main Authors:	Rui Luo, Ana-Maria Gomez, Jean-Pierre Benitah, Jessica Sabourin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-10-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	orai1 store-operated Ca2+ entry cardiomyocytes heart hypertrophy heart failure
Online Access:	https://www.frontiersin.org/article/10.3389/fcell.2020.586109/full

Similar Items

CaMKII Potentiates Store-Operated Ca2+ Entry Through Enhancing STIM1 Aggregation and Interaction with Orai1
by: Shu Li, et al.
Published: (2018-04-01)

Enhanced store-operated Ca2+ influx and ORAI1 expression in ventricular fibroblasts from human failing heart
by: Gracious R. Ross, et al.
Published: (2017-03-01)

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel
by: Samriddhi Arora, et al.
Published: (2021-11-01)

Gastrodin Inhibits Store-Operated Ca2+ Entry and Alleviates Cardiac Hypertrophy
by: Xiaoqiang Yao, et al.
Published: (2017-04-01)

Orai2 Modulates Store-Operated Ca<sup>2+</sup> Entry and Cell Cycle Progression in Breast Cancer Cells
by: Jose Sanchez-Collado, et al.
Published: (2021-12-01)

Store-operated calcium entry and the localisation of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells
by: Jie eLiu, et al.
Published: (2015-03-01)

Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1–STIM1 complex
by: Jinsen Lu, et al.
Published: (2019-08-01)

CaMKII-δ9 Induces Cardiomyocyte Death to Promote Cardiomyopathy and Heart Failure
by: Mao Zhang, et al.
Published: (2022-01-01)

Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle
by: Antonio Michelucci, et al.
Published: (2019-10-01)

Suppression of store-operated calcium entry causes dilated cardiomyopathy of the Drosophila heart
by: Courtney E. Petersen, et al.
Published: (2020-03-01)

TRPC1 channel clustering during store-operated Ca2+ entry in keratinocytes
by: Declan Manning, et al.
Published: (2023-03-01)

Store-Operated Calcium Entry and Its Implications in Cancer Stem Cells
by: Isaac Jardin, et al.
Published: (2022-04-01)

The Molecular Heterogeneity of Store-Operated Ca<sup>2+</sup> Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1/TRPC4 Channels in the Transition from Ca<sup>2+</sup>-Selective to Non-Selective Cation Currents
by: Francesco Moccia, et al.
Published: (2023-02-01)

Store-Operated Ca2+ Entry (SOCE) contributes to angiotensin II-induced cardiac fibrosis in cardiac fibroblasts
by: Boyu Zhang, et al.
Published: (2016-11-01)

ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca<sup>2+</sup> Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ
by: Mario G. Pavez-Giani, et al.
Published: (2021-04-01)

STIM and Orai1 variants in store-operated calcium entry
by: JUAN ANTONIO ROSADO, et al.
Published: (2016-01-01)

Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons
by: Dongyu Wei, et al.
Published: (2017-12-01)

Store-Operated Ca<sup>2+</sup> Entry in Tumor Progression: From Molecular Mechanisms to Clinical Implications
by: Yih-Fung Chen, et al.
Published: (2019-06-01)

Store-Operated Calcium Entry in Skeletal Muscle: What Makes It Different?
by: Elena Lilliu, et al.
Published: (2021-09-01)

Comprehensive Assessment of the STIMs and Orais Expression in Polycystic Ovary Syndrome
by: Tian Song, et al.
Published: (2022-05-01)

Corrigendum: Comprehensive assessment of the STIMs and Orais expression in polycystic ovary syndrome
by: Tian Song, et al.
Published: (2022-08-01)

Role of Orai3 in the Pathophysiology of Cancer
by: Jose Sanchez-Collado, et al.
Published: (2021-10-01)

Regulatory mechanisms controlling store-operated calcium entry
by: Goutham Kodakandla, et al.
Published: (2023-12-01)

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis
by: Ayat S. Hammad, et al.
Published: (2021-05-01)

TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure
by: Isaac Jardin, et al.
Published: (2018-09-01)

Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation
by: Jose Sanchez-Collado, et al.
Published: (2022-12-01)

Blocking Store-Operated Ca<sup>2+</sup> Entry to Protect HL-1 Cardiomyocytes from Epirubicin-Induced Cardiotoxicity
by: Xian Liu, et al.
Published: (2023-02-01)

Impact of SOCE Abolition by ORAI1 Knockout on the Proliferation, Adhesion, and Migration of HEK-293 Cells
by: Alexandre Bokhobza, et al.
Published: (2021-11-01)

The Ca<sup>2+</sup> Sensor STIM in Human Diseases
by: Alejandro Berna-Erro, et al.
Published: (2023-08-01)

Regulation of Store-Operated Ca<sup>2+</sup> Entry by SARAF
by: Inbal Dagan, et al.
Published: (2021-07-01)

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
by: Priscilla S-W Yeung, et al.
Published: (2023-02-01)

STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
by: F.R. Giachini, et al.
Published: (2011-11-01)

STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
by: F.R. Giachini, et al.
Published: (2011-11-01)

ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological Vascular Remodelling
by: Heba Shawer, et al.
Published: (2021-04-01)

STIM1-mediated bidirectional regulation of Ca2+ entry through Voltage-Gated Calcium Channels (VGCC) and Calcium-Release Activated Channels (CRAC)
by: Osama F. Harraz, et al.
Published: (2014-02-01)

NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells
by: Beibei Wu, et al.
Published: (2021-08-01)

Role of Orai3-Mediated Store-Operated Calcium Entry in Radiation-Induced Brain Microvascular Endothelial Cell Injury
by: Qibing Wu, et al.
Published: (2023-04-01)

ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells
by: Elena Scremin, et al.
Published: (2020-07-01)

Physiological functions of calcium signaling via Orai1 in cancer
by: Masanari Umemura, et al.
Published: (2023-09-01)

High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts
by: Maki Kimura, et al.
Published: (2018-05-01)