Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets
Preparative chemistry combines theoretical complexity and arduous practical work in the laboratory. As a result, chemists often spend long hours waiting for products to react, dry, separate, and crystallize or to be analyzed. Partial relief from waiting comes with today's broad access...
| Main Authors: | , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2008-02-01
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| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://chimia.ch/chimia/article/view/4426 |
| _version_ | 1811320324544790528 |
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| author | Samuel C. Halim Wendelin J. Stark |
| author_facet | Samuel C. Halim Wendelin J. Stark |
| author_sort | Samuel C. Halim |
| collection | DOAJ |
| description |
Preparative chemistry combines theoretical complexity and arduous practical work in the laboratory. As a result, chemists often spend long hours waiting for products to react, dry, separate, and crystallize or to be analyzed. Partial relief from waiting comes with today's broad access
to efficient and elegant synthetic methods. The present contribution addresses the time-consuming work between the actual chemical reaction steps where labor-intensive work is done manually. Even the most skillful chemists admit that reactions typically run on their own while personal time
is largely spent on the workup and, most important, on their planning. This article demonstrates how covalently functionalized cobalt nanomagnets can offer an unconventional way to significantly speed up separation of reagents or products in synthesis. Combining concepts from Merrifield chemistry
and making use of novel materials preparation methods, reagents or synthetic intermediates can now be covalently attached to nanomagnets. With a size range of 10–50 nm, the tiny metal particles have sufficient specific surface area to attach molecules at a capacity close to presently
used Wang resins or Merrifield chemistry. A synthesis can now be run in the presence of the magnetic helping agents and, if necessary, the tagged compounds can be removed from the reaction mixture within seconds. While magnetic molecule separation is still in its infancy, the present review
offers insight into the materials origins and first applications.
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| first_indexed | 2024-04-13T12:57:42Z |
| format | Article |
| id | doaj.art-6bcbfc514ea7488db4aa7de05839413d |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-04-13T12:57:42Z |
| publishDate | 2008-02-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-6bcbfc514ea7488db4aa7de05839413d2022-12-22T02:46:00ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242008-02-01621-210.2533/chimia.2008.13Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized NanomagnetsSamuel C. HalimWendelin J. Stark Preparative chemistry combines theoretical complexity and arduous practical work in the laboratory. As a result, chemists often spend long hours waiting for products to react, dry, separate, and crystallize or to be analyzed. Partial relief from waiting comes with today's broad access to efficient and elegant synthetic methods. The present contribution addresses the time-consuming work between the actual chemical reaction steps where labor-intensive work is done manually. Even the most skillful chemists admit that reactions typically run on their own while personal time is largely spent on the workup and, most important, on their planning. This article demonstrates how covalently functionalized cobalt nanomagnets can offer an unconventional way to significantly speed up separation of reagents or products in synthesis. Combining concepts from Merrifield chemistry and making use of novel materials preparation methods, reagents or synthetic intermediates can now be covalently attached to nanomagnets. With a size range of 10–50 nm, the tiny metal particles have sufficient specific surface area to attach molecules at a capacity close to presently used Wang resins or Merrifield chemistry. A synthesis can now be run in the presence of the magnetic helping agents and, if necessary, the tagged compounds can be removed from the reaction mixture within seconds. While magnetic molecule separation is still in its infancy, the present review offers insight into the materials origins and first applications. https://chimia.ch/chimia/article/view/4426Core/shellGrapheneMerrifield synthesisNanoparticleSolid-phase synthesis |
| spellingShingle | Samuel C. Halim Wendelin J. Stark Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets CHIMIA Core/shell Graphene Merrifield synthesis Nanoparticle Solid-phase synthesis |
| title | Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets |
| title_full | Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets |
| title_fullStr | Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets |
| title_full_unstemmed | Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets |
| title_short | Towards Magnetic Molecule and Reagent Separation in Organic Synthesis: Development and Use of Covalently Functionalized Nanomagnets |
| title_sort | towards magnetic molecule and reagent separation in organic synthesis development and use of covalently functionalized nanomagnets |
| topic | Core/shell Graphene Merrifield synthesis Nanoparticle Solid-phase synthesis |
| url | https://chimia.ch/chimia/article/view/4426 |
| work_keys_str_mv | AT samuelchalim towardsmagneticmoleculeandreagentseparationinorganicsynthesisdevelopmentanduseofcovalentlyfunctionalizednanomagnets AT wendelinjstark towardsmagneticmoleculeandreagentseparationinorganicsynthesisdevelopmentanduseofcovalentlyfunctionalizednanomagnets |