Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial
Abstract Background Asthma is considered to be a chronic inflammatory disorder of the airways. Probiotics are living microorganisms that are found in the human gut and have protective effects against a wide range of diseases such as allergies. The aim of this study was to investigate the improvement...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Allergy, Asthma & Clinical Immunology |
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| Online Access: | https://doi.org/10.1186/s13223-022-00753-4 |
| _version_ | 1797958643018104832 |
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| author | Sina Sadrifar Tannaz Abbasi-Dokht Sarvenaz Forouzandeh Farhad Malek Bahman Yousefi Amir Salek Farrokhi Jafar Karami Rasoul Baharlou |
| author_facet | Sina Sadrifar Tannaz Abbasi-Dokht Sarvenaz Forouzandeh Farhad Malek Bahman Yousefi Amir Salek Farrokhi Jafar Karami Rasoul Baharlou |
| author_sort | Sina Sadrifar |
| collection | DOAJ |
| description | Abstract Background Asthma is considered to be a chronic inflammatory disorder of the airways. Probiotics are living microorganisms that are found in the human gut and have protective effects against a wide range of diseases such as allergies. The aim of this study was to investigate the improvement of clinical asthma symptoms and changes in the expression pattern of selective microRNAs in patients with asthma and the changes in IL-4 and IFN-γ plasma levels after receiving probiotics. Materials and methods The present study was a randomized, double-blind, placebo-controlled trial that enrolled 40 asthmatic patients. They were treated with probiotics or placebo: 1 capsule/day for 8 weeks. Pulmonary function tests, IL-4 and IFN-γ levels, and expression of microRNAs were assessed at baseline and after treatment. Results The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. In addition, pulmonary function tests showed a significant improvement in Forced Expiratory Volume in 1 s and Forced Vital Capacity after receiving probiotics. Conclusion In our study, 8-week treatment with probiotic supplementation led to reduced Th2 cells-associated IL-4 and improved Forced Expiratory Volume and Forced Vital Capacity. It appears probiotics can be used in addition to common asthma treatments. |
| first_indexed | 2024-04-11T00:21:53Z |
| format | Article |
| id | doaj.art-6bceb6fe28e742f5b8c3ce9117d0907b |
| institution | Directory Open Access Journal |
| issn | 1710-1492 |
| language | English |
| last_indexed | 2024-04-11T00:21:53Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Allergy, Asthma & Clinical Immunology |
| spelling | doaj.art-6bceb6fe28e742f5b8c3ce9117d0907b2023-01-08T12:14:37ZengBMCAllergy, Asthma & Clinical Immunology1710-14922023-01-0119111010.1186/s13223-022-00753-4Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trialSina Sadrifar0Tannaz Abbasi-Dokht1Sarvenaz Forouzandeh2Farhad Malek3Bahman Yousefi4Amir Salek Farrokhi5Jafar Karami6Rasoul Baharlou7Department of Immunology, School of Medicine, Semnan University of Medical SciencesDepartment of Immunology, School of Medicine, Semnan University of Medical SciencesDepartment of Internal medicine, Kosar Hospital, Semnan University of Medical SciencesDepartment of Internal medicine, Kosar Hospital, Semnan University of Medical SciencesDepartment of Immunology, School of Medicine, Semnan University of Medical SciencesDepartment of Immunology, Pasteur InstituteMolecular and Medicine Research Center, Khomein University of Medical SciencesDepartment of Immunology, School of Medicine, Semnan University of Medical SciencesAbstract Background Asthma is considered to be a chronic inflammatory disorder of the airways. Probiotics are living microorganisms that are found in the human gut and have protective effects against a wide range of diseases such as allergies. The aim of this study was to investigate the improvement of clinical asthma symptoms and changes in the expression pattern of selective microRNAs in patients with asthma and the changes in IL-4 and IFN-γ plasma levels after receiving probiotics. Materials and methods The present study was a randomized, double-blind, placebo-controlled trial that enrolled 40 asthmatic patients. They were treated with probiotics or placebo: 1 capsule/day for 8 weeks. Pulmonary function tests, IL-4 and IFN-γ levels, and expression of microRNAs were assessed at baseline and after treatment. Results The results showed that the expression of miR-16, miR146-a and IL-4 levels in patients with asthma after receiving probiotic supplementation was significantly reduced and miR-133b expression was increased. In addition, pulmonary function tests showed a significant improvement in Forced Expiratory Volume in 1 s and Forced Vital Capacity after receiving probiotics. Conclusion In our study, 8-week treatment with probiotic supplementation led to reduced Th2 cells-associated IL-4 and improved Forced Expiratory Volume and Forced Vital Capacity. It appears probiotics can be used in addition to common asthma treatments.https://doi.org/10.1186/s13223-022-00753-4AsthmaProbioticMicroRNAIL-4IFN-γ |
| spellingShingle | Sina Sadrifar Tannaz Abbasi-Dokht Sarvenaz Forouzandeh Farhad Malek Bahman Yousefi Amir Salek Farrokhi Jafar Karami Rasoul Baharlou Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial Allergy, Asthma & Clinical Immunology Asthma Probiotic MicroRNA IL-4 IFN-γ |
| title | Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial |
| title_full | Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial |
| title_fullStr | Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial |
| title_short | Immunomodulatory effects of probiotic supplementation in patients with asthma: a randomized, double-blind, placebo-controlled trial |
| title_sort | immunomodulatory effects of probiotic supplementation in patients with asthma a randomized double blind placebo controlled trial |
| topic | Asthma Probiotic MicroRNA IL-4 IFN-γ |
| url | https://doi.org/10.1186/s13223-022-00753-4 |
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