Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

Rutin Gel with Bone Graft Accelerates Bone Formation in a Rabbit Model by Inhibiting MMPs and Enhancing Collagen Activities

Bone graft techniques are used to compensate for bone loss in areas with deficient regeneration. However, matrix metalloproteases (MMPs) can limit bone formation by degrading extracellular matrices, which are required for bone regrowth. Noteworthily, rutin is a natural flavonoid compound that inhibi...

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Bibliographic Details
Main Authors: Fahad F. Albaqami, Hassan N. Althurwi, Khalid M. Alharthy, Abubaker M. Hamad, Fatin A. Awartani
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
rutin
matrix metalloprotease (MMP)
extracellular matrix (ECM)
bone graft
collagen
natural product
Online Access:https://www.mdpi.com/1424-8247/16/5/774

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