Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage
Abstract Peripheral sensory organ damage leads to compensatory cortical plasticity that is associated with a remarkable recovery of cortical responses to sound. The precise mechanisms that explain how this plasticity is implemented and distributed over a diverse collection of excitatory and inhibito...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-39732-7 |
| _version_ | 1797778767286894592 |
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| author | Manoj Kumar Gregory Handy Stylianos Kouvaros Yanjun Zhao Lovisa Ljungqvist Brinson Eric Wei Brandon Bizup Brent Doiron Thanos Tzounopoulos |
| author_facet | Manoj Kumar Gregory Handy Stylianos Kouvaros Yanjun Zhao Lovisa Ljungqvist Brinson Eric Wei Brandon Bizup Brent Doiron Thanos Tzounopoulos |
| author_sort | Manoj Kumar |
| collection | DOAJ |
| description | Abstract Peripheral sensory organ damage leads to compensatory cortical plasticity that is associated with a remarkable recovery of cortical responses to sound. The precise mechanisms that explain how this plasticity is implemented and distributed over a diverse collection of excitatory and inhibitory cortical neurons remain unknown. After noise trauma and persistent peripheral deficits, we found recovered sound-evoked activity in mouse A1 excitatory principal neurons (PNs), parvalbumin- and vasoactive intestinal peptide-expressing neurons (PVs and VIPs), but reduced activity in somatostatin-expressing neurons (SOMs). This cell-type-specific recovery was also associated with cell-type-specific intrinsic plasticity. These findings, along with our computational modelling results, are consistent with the notion that PV plasticity contributes to PN stability, SOM plasticity allows for increased PN and PV activity, and VIP plasticity enables PN and PV recovery by inhibiting SOMs. |
| first_indexed | 2024-03-12T23:22:17Z |
| format | Article |
| id | doaj.art-6bd1c884e1c64a5380722f9498c210c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-12T23:22:17Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6bd1c884e1c64a5380722f9498c210c42023-07-16T11:21:38ZengNature PortfolioNature Communications2041-17232023-07-0114112310.1038/s41467-023-39732-7Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damageManoj Kumar0Gregory Handy1Stylianos Kouvaros2Yanjun Zhao3Lovisa Ljungqvist Brinson4Eric Wei5Brandon Bizup6Brent Doiron7Thanos Tzounopoulos8Pittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghDepartments of Neurobiology and Statistics, University of ChicagoPittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghPittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghPittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghPittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghPittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghDepartments of Neurobiology and Statistics, University of ChicagoPittsburgh Hearing Research Center, Department of Otolaryngology, University of PittsburghAbstract Peripheral sensory organ damage leads to compensatory cortical plasticity that is associated with a remarkable recovery of cortical responses to sound. The precise mechanisms that explain how this plasticity is implemented and distributed over a diverse collection of excitatory and inhibitory cortical neurons remain unknown. After noise trauma and persistent peripheral deficits, we found recovered sound-evoked activity in mouse A1 excitatory principal neurons (PNs), parvalbumin- and vasoactive intestinal peptide-expressing neurons (PVs and VIPs), but reduced activity in somatostatin-expressing neurons (SOMs). This cell-type-specific recovery was also associated with cell-type-specific intrinsic plasticity. These findings, along with our computational modelling results, are consistent with the notion that PV plasticity contributes to PN stability, SOM plasticity allows for increased PN and PV activity, and VIP plasticity enables PN and PV recovery by inhibiting SOMs.https://doi.org/10.1038/s41467-023-39732-7 |
| spellingShingle | Manoj Kumar Gregory Handy Stylianos Kouvaros Yanjun Zhao Lovisa Ljungqvist Brinson Eric Wei Brandon Bizup Brent Doiron Thanos Tzounopoulos Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage Nature Communications |
| title | Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage |
| title_full | Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage |
| title_fullStr | Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage |
| title_full_unstemmed | Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage |
| title_short | Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage |
| title_sort | cell type specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage |
| url | https://doi.org/10.1038/s41467-023-39732-7 |
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