DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders

DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders

The damage and repair of DNA is a continuous process required to maintain genomic integrity. DNA double-strand breaks (DSBs) are the most lethal type of DNA damage and require timely repair by dedicated machinery. DSB repair is uniquely important to nondividing, post-mitotic cells of the central ner...

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Bibliographic Details
Main Authors: Vincent E. Provasek, Joy Mitra, Vikas H. Malojirao, Muralidhar L. Hegde
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
TDP-43
hnRNPs
DNA double-strand break repair
DNA damage response
neurodegeneration
dementia
Online Access:https://www.mdpi.com/1422-0067/23/9/4653

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