Development of Machine Learning Models for Accurately Predicting and Ranking the Activity of Lead Molecules to Inhibit PRC2 Dependent Cancer

Development of Machine Learning Models for Accurately Predicting and Ranking the Activity of Lead Molecules to Inhibit PRC2 Dependent Cancer

Disruption of epigenetic processes to eradicate tumor cells is among the most promising interventions for cancer control. EZH2 (Enhancer of zeste homolog 2), a catalytic component of polycomb repressive complex 2 (PRC2), methylates lysine 27 of histone H3 to promote transcriptional silencing and is...

Bibliografiset tiedot
Päätekijät:	Danishuddin, Vikas Kumar, Shraddha Parate, Ashutosh Bahuguna, Gihwan Lee, Myeong Ok Kim, Keun Woo Lee
Aineistotyyppi:	Artikkeli
Kieli:	English
Julkaistu:	MDPI AG 2021-07-01
Sarja:	Pharmaceuticals
Aiheet:	cancer epigenetic PRC2 machine learning multi-class models
Linkit:	https://www.mdpi.com/1424-8247/14/7/699

Samankaltaisia teoksia

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR
Tekijä: Adhikarimayum Lakhikumar Sharma, et al.
Julkaistu: (2020-09-01)

Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins
Tekijä: Steven Z DeLuca, et al.
Julkaistu: (2020-08-01)

The competence paradigm of the future teacher of choreography: the experience of the PRC
Tekijä: O. Bashkir, et al.
Julkaistu: (2022-10-01)

Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function
Tekijä: Zhiwei Zhou, et al.
Julkaistu: (2017-11-01)

The PRC2 complex epigenetically silences GATA4 to suppress cellular senescence and promote the progression of breast cancer
Tekijä: Wenqian Yu, et al.
Julkaistu: (2024-08-01)

Features of Assessing the Image of the PRC Abroad on the Example of News Coverage of COVID-19
Tekijä: N. S. Ivannikov, et al.
Julkaistu: (2024-07-01)

Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory
Tekijä: Cecilia Lövkvist, et al.
Julkaistu: (2021-09-01)

AMPK lifts the PRC2-implemented gene repression
Tekijä: Tao Han, et al.
Julkaistu: (2018-05-01)

Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance
Tekijä: Jessica M. Stringer, et al.
Julkaistu: (2018-09-01)

Foreign Translators Group in the PRC From 1949 to 1966: A STP Perspective
Tekijä: Chen Longzhan
Julkaistu: (2024-12-01)

Identification of MltG as a Prc Protease Substrate Whose Dysregulation Contributes to the Conditional Growth Defect of Prc-Deficient Escherichia coli
Tekijä: Po-Chuen Hsu, et al.
Julkaistu: (2020-08-01)

ECONOMIC COOP TENDENCIES BETWEEN RUSSIA AND PRC
Tekijä: N. Krivorotova, et al.
Julkaistu: (2022-02-01)

Research advances of polycomb group proteins in regulating mammalian development
Tekijä: Yan Li, et al.
Julkaistu: (2024-03-01)

An EED/PRC2‐H19 Loop Regulates Cerebellar Development
Tekijä: Pei‐Pei Liu, et al.
Julkaistu: (2025-01-01)

Tachycardia and fever after packed red cell (PRC) infusion: A case report
Tekijä: Swanand S. Pathak, et al.
Julkaistu: (2023-07-01)

Karakteristik Bayi Prematur yang Mengalami Anemia dan Tranfusi PRC Sebelum Usia Kronologis 4 Minggu
Tekijä: Made Satria Murti, et al.
Julkaistu: (2016-11-01)

UKRAINE AND MOLDOVA IN THE PRC REGIONAL POLICY
Tekijä: Liuying Wang
Julkaistu: (2018-12-01)

Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish
Tekijä: Ludivine Raby, et al.
Julkaistu: (2021-11-01)

The combined use of long non-coding RNA HOTAIR and polycomb group protein EZH2 as a prognostic marker of lung adenocarcinoma
Tekijä: Toshihiko Iizuka, et al.
Julkaistu: (2022-01-01)

On PRC Transport Sector
Tekijä: Anna Borisovna Bardal
Julkaistu: (2020-04-01)

Gambaran Kadar Hemoglobin pada Sediaan Produk Darah Packed Red Cells (PRC) selama Masa Simpan 20 hari
Tekijä: Wiwit Sepvianti, et al.
Julkaistu: (2019-07-01)

Pharmacological Advancements of PRC2 in Cancer Therapy: A Narrative Review
Tekijä: Michael S. Wang, et al.
Julkaistu: (2024-12-01)

Post-translational modifications of PRC2: signals directing its activity
Tekijä: Yiqi Yang, et al.
Julkaistu: (2020-10-01)

CDK16 promotes the progression and metastasis of triple-negative breast cancer by phosphorylating PRC1
Tekijä: Xiao Li, et al.
Julkaistu: (2022-04-01)

Causes, evolution and consequences of uneven regional development in the PRC in the modern period of history: an overview of approaches and practices in Chinese science
Tekijä: Svetlana Borisovna Makeeva
Julkaistu: (2021-12-01)

H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity
Tekijä: Yue Zhou, et al.
Julkaistu: (2017-04-01)

Influence of early Soviet symbols of Russia on the formation of the State power signs of the PRC in 1949
Tekijä: Alexandrova A.D.
Julkaistu: (2020-03-01)

Africa in the Foreign Policy Course of PRC
Tekijä: A A Zabella
Julkaistu: (2017-12-01)

Ideological Transformation of the PRC: Parallels with Late Socialism in the USSR
Tekijä: V. A. Skosyrev
Julkaistu: (2020-11-01)

Optogenetic control of PRC1 reveals its role in chromosome alignment on the spindle by overlap length-dependent forces
Tekijä: Mihaela Jagrić, et al.
Julkaistu: (2021-01-01)

Universities of China: Current Status and Global Development Strategy Until 2035
Tekijä: Tatiana L. Guruleva
Julkaistu: (2020-04-01)

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway
Tekijä: Ping Zhan, et al.
Julkaistu: (2017-06-01)

From Flies to Mice: The Emerging Role of Non-Canonical PRC1 Members in Mammalian Development
Tekijä: Izabella Bajusz, et al.
Julkaistu: (2018-02-01)

LncRNAs and PRC2: Coupled Partners in Embryonic Stem Cells
Tekijä: Alessandro Fiorenzano, et al.
Julkaistu: (2019-08-01)

The Influence of the Overseas Chinese on the Economic Development of the PRC
Tekijä: Afonaseva A.V.
Julkaistu: (2023-04-01)

Problems of economic and humanitarian cooperation between the PRC and the US
Tekijä: Kiryushina A.I.
Julkaistu: (2024-06-01)

Measuring the technological competitiveness of economies with the PTCE method: PRC vs. USA 2000–2020
Tekijä: Adam Woźnicki, et al.
Julkaistu: (2024-07-01)

Increasing Notch signaling antagonizes PRC2-mediated silencing to promote reprograming of germ cells into neurons
Tekijä: Stefanie Seelk, et al.
Julkaistu: (2016-09-01)

ZFP36 Binds With PRC1 to Inhibit Tumor Growth and Increase 5-Fu Chemosensitivity of Hepatocellular Carcinoma
Tekijä: Weiqian Chen, et al.
Julkaistu: (2020-07-01)

The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli
Tekijä: Wen-Chun Huang, et al.
Julkaistu: (2020-01-01)