The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

Summary: Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1–5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of...

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Main Authors: Christina Christoffersen, Christine K. Federspiel, Anna Borup, Pernille M. Christensen, Andreas N. Madsen, Markus Heine, Carsten H. Nielsen, Andreas Kjaer, Birgitte Holst, Joerg Heeren, Lars B. Nielsen
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717318387

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