Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers
The human papillomavirus (HPV) is a typical sexually transmitted disease that affects different epithelial cells and can cause a number of health problems. HPV is mainly spread through sexual contact and is extremely contagious, even in the absence of obvious symptoms. It is linked to a number of ma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-03-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748241238629 |
| _version_ | 1797265806411694080 |
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| author | Laraib Iqbal Minal Jehan Sumran Azam |
| author_facet | Laraib Iqbal Minal Jehan Sumran Azam |
| author_sort | Laraib Iqbal |
| collection | DOAJ |
| description | The human papillomavirus (HPV) is a typical sexually transmitted disease that affects different epithelial cells and can cause a number of health problems. HPV is mainly spread through sexual contact and is extremely contagious, even in the absence of obvious symptoms. It is linked to a number of malignancies, such as oropharyngeal, cervical, anal, vulvar, vaginal, and cutaneous as well as anogenital and cutaneous warts. Different vaccines targeting various HPV virus strains have been produced to prevent HPV infections. Vaccines can help prevent HPV-related illnesses, but they cannot cure malignancies that have already been caused by HPV. But new developments in mRNA vaccines have shown potential in combating malignancies linked to HPV. mRNA vaccines stimulate the immune system to identify and attack particular proteins present in viruses or tumour cells. The efficacy of mRNA vaccines in preventing HPV-related malignancies has been shown in preliminary experiments in mice. Additionally, in clinical trials aimed at individuals with HPV-related head and neck malignancies, personalised mRNA vaccines in combination with immune checkpoint drugs have demonstrated encouraging results. Even though mRNA vaccines have drawbacks and restrictions such as immunogenicity and instability, further research and development in this area has a great deal of promise for developing effective therapies for HPV-related malignancies. |
| first_indexed | 2024-04-25T00:50:39Z |
| format | Article |
| id | doaj.art-6bdaf3540957418a99e128998dd123e2 |
| institution | Directory Open Access Journal |
| issn | 1526-2359 |
| language | English |
| last_indexed | 2024-04-25T00:50:39Z |
| publishDate | 2024-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-6bdaf3540957418a99e128998dd123e22024-03-11T18:05:50ZengSAGE PublishingCancer Control1526-23592024-03-013110.1177/10732748241238629Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related CancersLaraib IqbalMinal JehanSumran AzamThe human papillomavirus (HPV) is a typical sexually transmitted disease that affects different epithelial cells and can cause a number of health problems. HPV is mainly spread through sexual contact and is extremely contagious, even in the absence of obvious symptoms. It is linked to a number of malignancies, such as oropharyngeal, cervical, anal, vulvar, vaginal, and cutaneous as well as anogenital and cutaneous warts. Different vaccines targeting various HPV virus strains have been produced to prevent HPV infections. Vaccines can help prevent HPV-related illnesses, but they cannot cure malignancies that have already been caused by HPV. But new developments in mRNA vaccines have shown potential in combating malignancies linked to HPV. mRNA vaccines stimulate the immune system to identify and attack particular proteins present in viruses or tumour cells. The efficacy of mRNA vaccines in preventing HPV-related malignancies has been shown in preliminary experiments in mice. Additionally, in clinical trials aimed at individuals with HPV-related head and neck malignancies, personalised mRNA vaccines in combination with immune checkpoint drugs have demonstrated encouraging results. Even though mRNA vaccines have drawbacks and restrictions such as immunogenicity and instability, further research and development in this area has a great deal of promise for developing effective therapies for HPV-related malignancies.https://doi.org/10.1177/10732748241238629 |
| spellingShingle | Laraib Iqbal Minal Jehan Sumran Azam Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers Cancer Control |
| title | Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers |
| title_full | Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers |
| title_fullStr | Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers |
| title_full_unstemmed | Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers |
| title_short | Advancements in mRNA Vaccines: A Promising Approach for Combating Human Papillomavirus-Related Cancers |
| title_sort | advancements in mrna vaccines a promising approach for combating human papillomavirus related cancers |
| url | https://doi.org/10.1177/10732748241238629 |
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