Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India
Prediabetes is the precursor stage of diabetes mellitus and is also considered to be a risk factor for the development of cardiovascular disease. Atherogenic indices have been used for assessment of risk for cardiovascular disease development. To date, there is no data on evaluating the relationship...
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MDPI AG
2018-07-01
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| Series: | Medical Sciences |
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| author | Roshan Kumar Mahat Neelima Singh Vedika Rathore Akshara Gupta Rakesh Kumar Shah |
| author_facet | Roshan Kumar Mahat Neelima Singh Vedika Rathore Akshara Gupta Rakesh Kumar Shah |
| author_sort | Roshan Kumar Mahat |
| collection | DOAJ |
| description | Prediabetes is the precursor stage of diabetes mellitus and is also considered to be a risk factor for the development of cardiovascular disease. Atherogenic indices have been used for assessment of risk for cardiovascular disease development. To date, there is no data on evaluating the relationship between atherogenic indices (cardiac risk ratio (CRR), atherogenic coefficient (AC), and atherogenic index of plasma (AIP)) and carotid intima-media thickness (CIMT) in prediabetes. Hence, we aimed to determine atherogenic indices (CRR, AC, and AIP) and CIMT in prediabetic subjects and then sought to evaluate the relationship between them. A total of 400 human subjects were included in the present study, out of which 200 were prediabetic subjects and 200 were normal healthy control subjects. For each subject, CRR, AC, and AIP were calculated from routine lipid parameters and carotid intima-media thickness was measured as well. Atherogenic indices, that is, CRR, AC, and AIP, were significantly increased in prediabetic subjects as compared to the controls (5.87 ± 0.87 vs. 4.23 ± 0.50, p < 0.001; 4.87 ± 0.87 vs. 3.23 ± 0.50, p < 0.001; and 0.29 ± 0.07 vs. 0.09 ± 0.09, p < 0.001, respectively). Moreover, a significant and positive correlation was observed between CIMT and AIP (r = 0.529, p < 0.01), CRR (r = 0.495, p < 0.01), and AC (r = 0.495, p < 0.01). Prediabetic subjects present abnormalities in atherogenic indices and CIMT, which indicate a greater propensity of prediabetes for the development of cardiovascular disease. Hence, atherogenic indices can be used in addition to routine lipid parameters for the better assessment of subclinical atherosclerosis in prediabetic subjects. |
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| language | English |
| last_indexed | 2024-12-10T23:06:34Z |
| publishDate | 2018-07-01 |
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| record_format | Article |
| series | Medical Sciences |
| spelling | doaj.art-6bdb1016cf914e5980136fbd5f1335072022-12-22T01:30:02ZengMDPI AGMedical Sciences2076-32712018-07-01635510.3390/medsci6030055medsci6030055Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central IndiaRoshan Kumar Mahat0Neelima Singh1Vedika Rathore2Akshara Gupta3Rakesh Kumar Shah4Department of Biochemistry, Gajra Raja Medical College, Gwalior 474009, IndiaDepartment of Biochemistry, Gajra Raja Medical College, Gwalior 474009, IndiaDepartment of Biochemistry, Gajra Raja Medical College, Gwalior 474009, IndiaDepartment of Radiodiagnosis, Gajra Raja Medical College, Gwalior 474009, IndiaDepartment of Biochemistry, Gajra Raja Medical College, Gwalior 474009, IndiaPrediabetes is the precursor stage of diabetes mellitus and is also considered to be a risk factor for the development of cardiovascular disease. Atherogenic indices have been used for assessment of risk for cardiovascular disease development. To date, there is no data on evaluating the relationship between atherogenic indices (cardiac risk ratio (CRR), atherogenic coefficient (AC), and atherogenic index of plasma (AIP)) and carotid intima-media thickness (CIMT) in prediabetes. Hence, we aimed to determine atherogenic indices (CRR, AC, and AIP) and CIMT in prediabetic subjects and then sought to evaluate the relationship between them. A total of 400 human subjects were included in the present study, out of which 200 were prediabetic subjects and 200 were normal healthy control subjects. For each subject, CRR, AC, and AIP were calculated from routine lipid parameters and carotid intima-media thickness was measured as well. Atherogenic indices, that is, CRR, AC, and AIP, were significantly increased in prediabetic subjects as compared to the controls (5.87 ± 0.87 vs. 4.23 ± 0.50, p < 0.001; 4.87 ± 0.87 vs. 3.23 ± 0.50, p < 0.001; and 0.29 ± 0.07 vs. 0.09 ± 0.09, p < 0.001, respectively). Moreover, a significant and positive correlation was observed between CIMT and AIP (r = 0.529, p < 0.01), CRR (r = 0.495, p < 0.01), and AC (r = 0.495, p < 0.01). Prediabetic subjects present abnormalities in atherogenic indices and CIMT, which indicate a greater propensity of prediabetes for the development of cardiovascular disease. Hence, atherogenic indices can be used in addition to routine lipid parameters for the better assessment of subclinical atherosclerosis in prediabetic subjects.http://www.mdpi.com/2076-3271/6/3/55prediabetesatherogenic indicescarotid intima-media thicknessatherogenic index of plasma |
| spellingShingle | Roshan Kumar Mahat Neelima Singh Vedika Rathore Akshara Gupta Rakesh Kumar Shah Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India Medical Sciences prediabetes atherogenic indices carotid intima-media thickness atherogenic index of plasma |
| title | Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India |
| title_full | Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India |
| title_fullStr | Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India |
| title_full_unstemmed | Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India |
| title_short | Relationship between Atherogenic Indices and Carotid Intima-Media Thickness in Prediabetes: A Cross-Sectional Study from Central India |
| title_sort | relationship between atherogenic indices and carotid intima media thickness in prediabetes a cross sectional study from central india |
| topic | prediabetes atherogenic indices carotid intima-media thickness atherogenic index of plasma |
| url | http://www.mdpi.com/2076-3271/6/3/55 |
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