Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms

Abstract Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative symptoms and functional outcomes. Switch targets multiple cognitive...

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Main Authors: Bénédicte Thonon, Evelyne Van Aubel, Ginette Lafit, Clara Della Libera, Frank Larøi
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Psychiatry
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12888-020-02824-5
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author Bénédicte Thonon
Evelyne Van Aubel
Ginette Lafit
Clara Della Libera
Frank Larøi
author_facet Bénédicte Thonon
Evelyne Van Aubel
Ginette Lafit
Clara Della Libera
Frank Larøi
author_sort Bénédicte Thonon
collection DOAJ
description Abstract Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative symptoms and functional outcomes. Switch targets multiple cognitive, emotional and behavioural processes associated with motivation and goal directed behaviours. We aimed to investigate its effects on motivation and associated processes in a naturalistic setting, and to explore the dynamics between the processes. Methods We used a single case approach (n = 3), with a pre-post and follow-up assessment design, which also included ambulatory assessments (experience sampling method, ESM; and step count). We computed autoregressive lag 1 models to evaluate the effects of the intervention on daily motivation levels and related processes, descriptive pie-charts, and vector autoregressive modelling to reveal the dynamics of the processes over time. Results The intervention was beneficial for each participant according to traditional evaluations of motivational negative symptoms, apathy, daily functioning and quality of life. The effects on the ESM variables revealed distinct outcomes for each individual. The dynamics between the various processes differed between participants, and fluctuated within participants (when comparing baseline, intervention phase, and follow-up). Conclusions This study used an innovative approach to look at the effectiveness of an intervention. The intervention seems to lead to meaningful improvements in motivational negative symptoms and functional outcomes. The mechanisms of change need to be further investigated. Trial registration number ClinicalTrials.gov, NCT04325100 . Registered 27 March 27, 2020 -retrospectively registered. Reporting Guidelines from the Transparent Reporting of Evaluations with Non-randomized Designs (TREND) statement were followed.
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spelling doaj.art-6bdbd36b96ea4f48a17dc31a47361e9d2022-12-22T00:37:46ZengBMCBMC Psychiatry1471-244X2020-09-0120112210.1186/s12888-020-02824-5Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptomsBénédicte Thonon0Evelyne Van Aubel1Ginette Lafit2Clara Della Libera3Frank Larøi4Faculty of Psychology, Speech and Laguage Therapy and Education Sciences, Psychology and Neuroscience of Cognition Research Unit, University of LiègeDepartment of Neurosciences, Center for Contextual Psychiatry (CCP)Department of Neurosciences, Center for Contextual Psychiatry (CCP)Faculty of Psychology, Speech and Laguage Therapy and Education Sciences, Psychology and Neuroscience of Cognition Research Unit, University of LiègeFaculty of Psychology, Speech and Laguage Therapy and Education Sciences, Psychology and Neuroscience of Cognition Research Unit, University of LiègeAbstract Background Motivational negative symptoms hinder quality of life and daily functioning of individuals with schizophrenia spectrum disorders. A recently developed intervention, Switch, has shown promising effects on negative symptoms and functional outcomes. Switch targets multiple cognitive, emotional and behavioural processes associated with motivation and goal directed behaviours. We aimed to investigate its effects on motivation and associated processes in a naturalistic setting, and to explore the dynamics between the processes. Methods We used a single case approach (n = 3), with a pre-post and follow-up assessment design, which also included ambulatory assessments (experience sampling method, ESM; and step count). We computed autoregressive lag 1 models to evaluate the effects of the intervention on daily motivation levels and related processes, descriptive pie-charts, and vector autoregressive modelling to reveal the dynamics of the processes over time. Results The intervention was beneficial for each participant according to traditional evaluations of motivational negative symptoms, apathy, daily functioning and quality of life. The effects on the ESM variables revealed distinct outcomes for each individual. The dynamics between the various processes differed between participants, and fluctuated within participants (when comparing baseline, intervention phase, and follow-up). Conclusions This study used an innovative approach to look at the effectiveness of an intervention. The intervention seems to lead to meaningful improvements in motivational negative symptoms and functional outcomes. The mechanisms of change need to be further investigated. Trial registration number ClinicalTrials.gov, NCT04325100 . Registered 27 March 27, 2020 -retrospectively registered. Reporting Guidelines from the Transparent Reporting of Evaluations with Non-randomized Designs (TREND) statement were followed.http://link.springer.com/article/10.1186/s12888-020-02824-5ApathyInterventionEcological momentary assessmentTimeseries analyses, dynamicsSingle case
spellingShingle Bénédicte Thonon
Evelyne Van Aubel
Ginette Lafit
Clara Della Libera
Frank Larøi
Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
BMC Psychiatry
Apathy
Intervention
Ecological momentary assessment
Timeseries analyses, dynamics
Single case
title Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
title_full Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
title_fullStr Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
title_full_unstemmed Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
title_short Idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
title_sort idiographic analyses of motivation and related processes in participants with schizophrenia following a therapeutic intervention for negative symptoms
topic Apathy
Intervention
Ecological momentary assessment
Timeseries analyses, dynamics
Single case
url http://link.springer.com/article/10.1186/s12888-020-02824-5
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