Assessing the interplay of contrast, defocus, and resolution in cryo-EM: a benchmark experiment for limited dataset screening

Assessing the interplay of contrast, defocus, and resolution in cryo-EM: a benchmark experiment for limited dataset screening

Abstract The selection of defocus ranges for small datasets in cryo-electron microscopy (cryo-EM) is under-researched. We present a comprehensive benchmark experiment that aimed to evaluate the relationship between contrast, defocus, and resolution, particularly in the context of limited datasets. W...

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Bibliographic Details
Main Authors: Hayeon Lee, Yeseul Lee, Jinseok Lee, Hyeongseop Jeong, Dong Keon Yon, Clarissa L. Durie, Bumhan Ryu, Jeong Min Chung
Format: Article
Language:English
Published: SpringerOpen 2024-06-01
Series:Journal of Analytical Science and Technology
Subjects:
Cryo-electron microscopy (cryo-EM)
Contrast
Defocus
Resolution
Limited dataset
Artificial intelligence (AI)
Online Access:https://doi.org/10.1186/s40543-024-00445-1

Internet

https://doi.org/10.1186/s40543-024-00445-1

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