Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic immune-related disorder designated by a lack of tolerance to self-antigens and the over-secretion of autoantibodies against several cellular compartments. Although the exact pathophysiology of SLE has not been clarified yet, this disorder has a strong...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/6/937 |
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| author | Mohammad Taheri Reyhane Eghtedarian Marcel E. Dinger Soudeh Ghafouri-Fard |
| author_facet | Mohammad Taheri Reyhane Eghtedarian Marcel E. Dinger Soudeh Ghafouri-Fard |
| author_sort | Mohammad Taheri |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic immune-related disorder designated by a lack of tolerance to self-antigens and the over-secretion of autoantibodies against several cellular compartments. Although the exact pathophysiology of SLE has not been clarified yet, this disorder has a strong genetic component based on the results of familial aggregation and twin studies. Variation in the expression of non-coding RNAs has been shown to influence both susceptibility to SLE and the clinical course of this disorder. Several long non-coding RNAs (lncRNAs) such as GAS5, MALAT1 and NEAT1 are dysregulated in SLE patients. Moreover, genetic variants within lncRNAs such as SLEAR and linc00513 have been associated with risk of this disorder. The dysregulation of a number of lncRNAs in the peripheral blood of SLE patients has potentiated them as biomarkers for diagnosis, disease activity and therapeutic response. MicroRNAs (miRNAs) have also been shown to affect apoptosis and the function of immune cells. Taken together, there is a compelling rationale for the better understanding of the involvement of these two classes of non-coding RNAs in the pathogenesis of SLE. Clarification of the function of these transcripts has the potential to elucidate the molecular pathophysiology of SLE and provide new opportunities for the development of targeted therapies for this disorder. |
| first_indexed | 2024-03-10T18:58:16Z |
| format | Article |
| id | doaj.art-6bdc5c6c3ff8419887c988f7b5020276 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T18:58:16Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6bdc5c6c3ff8419887c988f7b50202762023-11-20T04:33:53ZengMDPI AGBiomolecules2218-273X2020-06-0110693710.3390/biom10060937Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus ErythematosusMohammad Taheri0Reyhane Eghtedarian1Marcel E. Dinger2Soudeh Ghafouri-Fard3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, IranDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, IranSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 1985717443, IranSystemic lupus erythematosus (SLE) is a chronic immune-related disorder designated by a lack of tolerance to self-antigens and the over-secretion of autoantibodies against several cellular compartments. Although the exact pathophysiology of SLE has not been clarified yet, this disorder has a strong genetic component based on the results of familial aggregation and twin studies. Variation in the expression of non-coding RNAs has been shown to influence both susceptibility to SLE and the clinical course of this disorder. Several long non-coding RNAs (lncRNAs) such as GAS5, MALAT1 and NEAT1 are dysregulated in SLE patients. Moreover, genetic variants within lncRNAs such as SLEAR and linc00513 have been associated with risk of this disorder. The dysregulation of a number of lncRNAs in the peripheral blood of SLE patients has potentiated them as biomarkers for diagnosis, disease activity and therapeutic response. MicroRNAs (miRNAs) have also been shown to affect apoptosis and the function of immune cells. Taken together, there is a compelling rationale for the better understanding of the involvement of these two classes of non-coding RNAs in the pathogenesis of SLE. Clarification of the function of these transcripts has the potential to elucidate the molecular pathophysiology of SLE and provide new opportunities for the development of targeted therapies for this disorder.https://www.mdpi.com/2218-273X/10/6/937lncRNAmiRNAsystemic lupus erythematosus |
| spellingShingle | Mohammad Taheri Reyhane Eghtedarian Marcel E. Dinger Soudeh Ghafouri-Fard Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus Biomolecules lncRNA miRNA systemic lupus erythematosus |
| title | Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus |
| title_full | Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus |
| title_fullStr | Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus |
| title_full_unstemmed | Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus |
| title_short | Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus |
| title_sort | exploring the role of non coding rnas in the pathophysiology of systemic lupus erythematosus |
| topic | lncRNA miRNA systemic lupus erythematosus |
| url | https://www.mdpi.com/2218-273X/10/6/937 |
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