Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan
Abstract The control rate of hypertension remains concerning, indicating the requirement for better management strategies. The calcium channel blockers brand‐name amlodipine and nifedipine with extended‐release formulations demonstrate similar clinical efficacy. However, the efficacy of generic nife...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-07-01
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| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14521 |
| _version_ | 1827778883521347584 |
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| author | Hao‐Wei Lee Chin‐Chou Huang Hsin‐Bang Leu Yenn‐Jiang Lin |
| author_facet | Hao‐Wei Lee Chin‐Chou Huang Hsin‐Bang Leu Yenn‐Jiang Lin |
| author_sort | Hao‐Wei Lee |
| collection | DOAJ |
| description | Abstract The control rate of hypertension remains concerning, indicating the requirement for better management strategies. The calcium channel blockers brand‐name amlodipine and nifedipine with extended‐release formulations demonstrate similar clinical efficacy. However, the efficacy of generic nifedipine remains obscure. We compared the efficacy of generic nifedipine and brand‐name amlodipine in terms of cardiovascular (CV) outcomes. Patients prescribed generic nifedipine (SRFC CYH) or brand‐name amlodipine besylate (Norvasc, Pfizer) between August 1, 2017, and July 31, 2018, were enrolled; patients with CV events within 3 months were excluded. CV outcomes included CV death, nonfatal myocardial infarction (MI), nonfatal ischemic stroke, hospitalization for heart failure, and composite endpoints of 3P‐ and 4P‐major adverse cardiac events (MACE). A total of 1625 patients treated with nifedipine (SRFC CYH) and 16 587 patients treated with Norvasc were included. After propensity score matching, there were 995 and 4975 patients in the nifedipine CYH and Norvasc groups, respectively. At a mean follow‐up period of 30.3 ± 6.4 months, nifedipine CYH was comparable to Norvasc in terms of CV death (P = .107), nonfatal MI (P = .121), nonfatal ischemic stroke (P = .453), hospitalization for heart failure (P = .330), 3P‐MACE (P = .584), and 4P‐MACE (P = .274). Cox regression analysis revealed that nifedipine CYH and Norvasc had similar efficacy in terms of 3P‐MACE (hazard ratio, 0.970; 95% confidence interval, 0.601–1.565, P = .900) and 4P‐MACE (hazard ratio, 0.880; 95% confidence interval, 0.628–1.233, P = .459). In conclusion, Nifedipine SRFC CYH and Norvasc have comparable clinical efficacy for hypertension management. |
| first_indexed | 2024-03-11T14:43:22Z |
| format | Article |
| id | doaj.art-6bdcdfa8ac8145129dcc803853826fed |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:43:22Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-6bdcdfa8ac8145129dcc803853826fed2023-10-30T13:26:30ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-07-0124787087710.1111/jch.14521Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in TaiwanHao‐Wei Lee0Chin‐Chou Huang1Hsin‐Bang Leu2Yenn‐Jiang Lin3Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei TaiwanDivision of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei TaiwanDivision of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei TaiwanDivision of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei TaiwanAbstract The control rate of hypertension remains concerning, indicating the requirement for better management strategies. The calcium channel blockers brand‐name amlodipine and nifedipine with extended‐release formulations demonstrate similar clinical efficacy. However, the efficacy of generic nifedipine remains obscure. We compared the efficacy of generic nifedipine and brand‐name amlodipine in terms of cardiovascular (CV) outcomes. Patients prescribed generic nifedipine (SRFC CYH) or brand‐name amlodipine besylate (Norvasc, Pfizer) between August 1, 2017, and July 31, 2018, were enrolled; patients with CV events within 3 months were excluded. CV outcomes included CV death, nonfatal myocardial infarction (MI), nonfatal ischemic stroke, hospitalization for heart failure, and composite endpoints of 3P‐ and 4P‐major adverse cardiac events (MACE). A total of 1625 patients treated with nifedipine (SRFC CYH) and 16 587 patients treated with Norvasc were included. After propensity score matching, there were 995 and 4975 patients in the nifedipine CYH and Norvasc groups, respectively. At a mean follow‐up period of 30.3 ± 6.4 months, nifedipine CYH was comparable to Norvasc in terms of CV death (P = .107), nonfatal MI (P = .121), nonfatal ischemic stroke (P = .453), hospitalization for heart failure (P = .330), 3P‐MACE (P = .584), and 4P‐MACE (P = .274). Cox regression analysis revealed that nifedipine CYH and Norvasc had similar efficacy in terms of 3P‐MACE (hazard ratio, 0.970; 95% confidence interval, 0.601–1.565, P = .900) and 4P‐MACE (hazard ratio, 0.880; 95% confidence interval, 0.628–1.233, P = .459). In conclusion, Nifedipine SRFC CYH and Norvasc have comparable clinical efficacy for hypertension management.https://doi.org/10.1111/jch.14521amlodipinegenerichypertensionnifedipineoutcome |
| spellingShingle | Hao‐Wei Lee Chin‐Chou Huang Hsin‐Bang Leu Yenn‐Jiang Lin Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan The Journal of Clinical Hypertension amlodipine generic hypertension nifedipine outcome |
| title | Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan |
| title_full | Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan |
| title_fullStr | Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan |
| title_full_unstemmed | Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan |
| title_short | Comparative efficacy of generic nifedipine versus brand‐name amlodipine for hypertension management in Taiwan |
| title_sort | comparative efficacy of generic nifedipine versus brand name amlodipine for hypertension management in taiwan |
| topic | amlodipine generic hypertension nifedipine outcome |
| url | https://doi.org/10.1111/jch.14521 |
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