Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2
Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide. During the early stages of vaccination in Egypt, the ChAdOx1 nCoV-19 and BBIBP-CorV vaccines were the most distributed. The aim of this study was to compare the immune responses and short-term efficacies of these two vacc...
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MDPI AG
2022-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/9/1462 |
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| author | Ahmed Samir Abdelhafiz Asmaa Ali Mahmoud M. Kamel Eman Hasan Ahmed Douaa M. Sayed Rania M. Bakry |
| author_facet | Ahmed Samir Abdelhafiz Asmaa Ali Mahmoud M. Kamel Eman Hasan Ahmed Douaa M. Sayed Rania M. Bakry |
| author_sort | Ahmed Samir Abdelhafiz |
| collection | DOAJ |
| description | Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide. During the early stages of vaccination in Egypt, the ChAdOx1 nCoV-19 and BBIBP-CorV vaccines were the most distributed. The aim of this study was to compare the immune responses and short-term efficacies of these two vaccines. We recruited adults who received two doses of either vaccine. Samples were collected after the first dose of ChAdOx1 nCoV-1 and after the second dose of both vaccines. Antibodies against SARS-CoV-2 antigens were measured using LABScreen™ COVID Plus kits, and cell-mediated immune responses were assessed using flow cytometry. Of the 109 recruited subjects, 60 (55%) received the ChAdOx1 nCoV-19 vaccine, and the remainder received the BBIBP-CorV vaccine. The total antibody level did not significantly differ between the two groups. The level of the anti-spike subunit 2 (S2) antibody was significantly higher in the ChAdOx1 nCoV-19 group. The percentages of both total T cells and B cells were unaffected by the type of vaccination. However, the ChAdOx1 nCoV-1 vaccine was significantly associated with a higher percentage of CD8+ cells. The vaccines did not significantly differ in the number or severity of infections postvaccination. None of the participants were admitted to the hospital or died of COVID-19 infection. In conclusion, the BBIBP-CorV vaccine is associated with an immune response and protection against infection that is comparable to that of the ChAdOx1 nCoV-1 vaccine. Follow-up is needed to study the long-term protective effects of both vaccines. Inactivated vaccines are easier to manufacture in developing countries and their limited side effects may lead to better economic benefits by limiting the number of absences from work. |
| first_indexed | 2024-03-09T22:17:16Z |
| format | Article |
| id | doaj.art-6bdd40f3775848d4a2ce7dee1c7a01b2 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:17:16Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6bdd40f3775848d4a2ce7dee1c7a01b22023-11-23T19:21:32ZengMDPI AGVaccines2076-393X2022-09-01109146210.3390/vaccines10091462Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2Ahmed Samir Abdelhafiz0Asmaa Ali1Mahmoud M. Kamel2Eman Hasan Ahmed3Douaa M. Sayed4Rania M. Bakry5Department of Clinical Pathology, National Cancer Institute, Cairo University, Kasr Al-Aini Street, El-Khalig Square, Cairo 11796, EgyptDepartment of Pulmonary Medicine, Abbassia Chest Hospital, MOH, Cairo 11517, EgyptDepartment of Clinical Pathology, National Cancer Institute, Cairo University, Kasr Al-Aini Street, El-Khalig Square, Cairo 11796, EgyptDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71515, EgyptDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71515, EgyptDepartment of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71515, EgyptCoronavirus disease 2019 (COVID-19) has affected millions of people worldwide. During the early stages of vaccination in Egypt, the ChAdOx1 nCoV-19 and BBIBP-CorV vaccines were the most distributed. The aim of this study was to compare the immune responses and short-term efficacies of these two vaccines. We recruited adults who received two doses of either vaccine. Samples were collected after the first dose of ChAdOx1 nCoV-1 and after the second dose of both vaccines. Antibodies against SARS-CoV-2 antigens were measured using LABScreen™ COVID Plus kits, and cell-mediated immune responses were assessed using flow cytometry. Of the 109 recruited subjects, 60 (55%) received the ChAdOx1 nCoV-19 vaccine, and the remainder received the BBIBP-CorV vaccine. The total antibody level did not significantly differ between the two groups. The level of the anti-spike subunit 2 (S2) antibody was significantly higher in the ChAdOx1 nCoV-19 group. The percentages of both total T cells and B cells were unaffected by the type of vaccination. However, the ChAdOx1 nCoV-1 vaccine was significantly associated with a higher percentage of CD8+ cells. The vaccines did not significantly differ in the number or severity of infections postvaccination. None of the participants were admitted to the hospital or died of COVID-19 infection. In conclusion, the BBIBP-CorV vaccine is associated with an immune response and protection against infection that is comparable to that of the ChAdOx1 nCoV-1 vaccine. Follow-up is needed to study the long-term protective effects of both vaccines. Inactivated vaccines are easier to manufacture in developing countries and their limited side effects may lead to better economic benefits by limiting the number of absences from work.https://www.mdpi.com/2076-393X/10/9/1462COVID-19SARS-CoV-2EgyptChAdOx1 nCoV-1BBIBP-CorV |
| spellingShingle | Ahmed Samir Abdelhafiz Asmaa Ali Mahmoud M. Kamel Eman Hasan Ahmed Douaa M. Sayed Rania M. Bakry Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2 Vaccines COVID-19 SARS-CoV-2 Egypt ChAdOx1 nCoV-1 BBIBP-CorV |
| title | Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2 |
| title_full | Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2 |
| title_fullStr | Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2 |
| title_full_unstemmed | Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2 |
| title_short | Sinopharm’s BBIBP-CorV Vaccine and ChAdOx1 nCoV-19 Vaccine Are Associated with a Comparable Immune Response against SARS-CoV-2 |
| title_sort | sinopharm s bbibp corv vaccine and chadox1 ncov 19 vaccine are associated with a comparable immune response against sars cov 2 |
| topic | COVID-19 SARS-CoV-2 Egypt ChAdOx1 nCoV-1 BBIBP-CorV |
| url | https://www.mdpi.com/2076-393X/10/9/1462 |
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