Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer
Abstract More and more studies report that exosomes released by various cells can serve as a medium for information exchange between different cells. Through a deep understanding of the physical and chemical properties of exosomes, the researchers revealed a more precise molecular mechanism of its p...
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3379 |
| _version_ | 1826937840527736832 |
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| author | Jing Wu Zuojun Shen |
| author_facet | Jing Wu Zuojun Shen |
| author_sort | Jing Wu |
| collection | DOAJ |
| description | Abstract More and more studies report that exosomes released by various cells can serve as a medium for information exchange between different cells. Through a deep understanding of the physical and chemical properties of exosomes, the researchers revealed a more precise molecular mechanism of its participation in the process of intercellular communication. In particular, microRNA (miRNA) is found inside exosomes, as well as long noncoding RNA (lncRNA). Extensive evidence indicates that exosomal miRNAs participates in the occurrence and development of lung cancer and plays a variety of roles. Therefore, the release of RNA‐containing exosomes in many different kinds of body fluids has caused widespread interest among researchers. In this review, we report evidence from human studies involving miRNAs and other ncRNAs in exosomes associated with lung cancer as diagnostic and prognostic markers. Currently, there is a small amount of evidence that exosomal miRNAs can be used as early diagnosis and prognostic markers for lung cancer, and their exact role in lung cancer patients still needs further study. |
| first_indexed | 2024-04-09T15:57:18Z |
| format | Article |
| id | doaj.art-6be12313a41f488495e439e9981fb5a7 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2025-02-17T18:48:01Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-6be12313a41f488495e439e9981fb5a72024-12-11T08:05:11ZengWileyCancer Medicine2045-76342020-10-019196909692210.1002/cam4.3379Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancerJing Wu0Zuojun Shen1Department of Clinical Laboratory Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei Anhui P.R. ChinaDepartment of Clinical Laboratory Anhui Provincial Hospital Affiliated to Anhui Medical University Hefei Anhui P.R. ChinaAbstract More and more studies report that exosomes released by various cells can serve as a medium for information exchange between different cells. Through a deep understanding of the physical and chemical properties of exosomes, the researchers revealed a more precise molecular mechanism of its participation in the process of intercellular communication. In particular, microRNA (miRNA) is found inside exosomes, as well as long noncoding RNA (lncRNA). Extensive evidence indicates that exosomal miRNAs participates in the occurrence and development of lung cancer and plays a variety of roles. Therefore, the release of RNA‐containing exosomes in many different kinds of body fluids has caused widespread interest among researchers. In this review, we report evidence from human studies involving miRNAs and other ncRNAs in exosomes associated with lung cancer as diagnostic and prognostic markers. Currently, there is a small amount of evidence that exosomal miRNAs can be used as early diagnosis and prognostic markers for lung cancer, and their exact role in lung cancer patients still needs further study.https://doi.org/10.1002/cam4.3379biomarkerdiagnosticexosomal miRNAlung cancernon‐coding RNAprognostic |
| spellingShingle | Jing Wu Zuojun Shen Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer Cancer Medicine biomarker diagnostic exosomal miRNA lung cancer non‐coding RNA prognostic |
| title | Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer |
| title_full | Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer |
| title_fullStr | Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer |
| title_full_unstemmed | Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer |
| title_short | Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer |
| title_sort | exosomal mirnas as biomarkers for diagnostic and prognostic in lung cancer |
| topic | biomarker diagnostic exosomal miRNA lung cancer non‐coding RNA prognostic |
| url | https://doi.org/10.1002/cam4.3379 |
| work_keys_str_mv | AT jingwu exosomalmirnasasbiomarkersfordiagnosticandprognosticinlungcancer AT zuojunshen exosomalmirnasasbiomarkersfordiagnosticandprognosticinlungcancer |