Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study
Objective: To assess whether chronic endometritis (CE) affects embryo implantation in patients with repeated implantation failure (RIF). Materials and methods: We retrospectively analyzed 126 RIF patients who were never diagnosed with CE and received no prior antibiotic therapy. Endometrial specimen...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455922002777 |
| _version_ | 1828119657511387136 |
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| author | Yuye Li Yanhong Xu Shuyi Yu Shenglai Lin Wanru Chen Ruochun Lian Lianghui Diao Haixiang Sun Lijun Ding Yong Zeng |
| author_facet | Yuye Li Yanhong Xu Shuyi Yu Shenglai Lin Wanru Chen Ruochun Lian Lianghui Diao Haixiang Sun Lijun Ding Yong Zeng |
| author_sort | Yuye Li |
| collection | DOAJ |
| description | Objective: To assess whether chronic endometritis (CE) affects embryo implantation in patients with repeated implantation failure (RIF). Materials and methods: We retrospectively analyzed 126 RIF patients who were never diagnosed with CE and received no prior antibiotic therapy. Endometrial specimens obtained by endometrial scratching during mid-luteal phase were immunostained by CD138, a hallmark plasmacyte marker, to identify CE. Pregnancy outcome in RIF patients who underwent IVF-ET frozen-embryo within transfers 6 months after endometrial scratching was compared between women with and without CE. Results: The prevalence of CE in patients with RIF was found to be 11.9% (15/126). Moreover, a significantly reduced clinical pregnancy rate was observed in RIF patients with CE (20% vs. 46.85%; p = 0.04). The live birth rate also exhibited a decreasing trend in RIF patients with CE, although there was no statistically significant difference (20% vs. 41.58%; p = 0.109). Conclusions: CE may be involved in the failure of embryo implantation and reduced clinical pregnancy outcome in patients with RIF. |
| first_indexed | 2024-04-11T13:51:32Z |
| format | Article |
| id | doaj.art-6be31057ef294ea284e82d6bbe402828 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-04-11T13:51:32Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-6be31057ef294ea284e82d6bbe4028282022-12-22T04:20:34ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592022-11-01616984988Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective studyYuye Li0Yanhong Xu1Shuyi Yu2Shenglai Lin3Wanru Chen4Ruochun Lian5Lianghui Diao6Haixiang Sun7Lijun Ding8Yong Zeng9Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, ChinaCenter for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu, China; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, ChinaCenter for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu, China; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, ChinaCenter for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu, China; Center for Reproductive Medicine, Department of Obstetrics and Gynecology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, China; Clinical Center for Stem Cell Research, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, ChinaShenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproduction and Genetics, Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, Guangdong, China; Corresponding author. No. 1001, Fuqiang Road, Futian District, Shenzhen 518045, Guangdong Province, PR China.Objective: To assess whether chronic endometritis (CE) affects embryo implantation in patients with repeated implantation failure (RIF). Materials and methods: We retrospectively analyzed 126 RIF patients who were never diagnosed with CE and received no prior antibiotic therapy. Endometrial specimens obtained by endometrial scratching during mid-luteal phase were immunostained by CD138, a hallmark plasmacyte marker, to identify CE. Pregnancy outcome in RIF patients who underwent IVF-ET frozen-embryo within transfers 6 months after endometrial scratching was compared between women with and without CE. Results: The prevalence of CE in patients with RIF was found to be 11.9% (15/126). Moreover, a significantly reduced clinical pregnancy rate was observed in RIF patients with CE (20% vs. 46.85%; p = 0.04). The live birth rate also exhibited a decreasing trend in RIF patients with CE, although there was no statistically significant difference (20% vs. 41.58%; p = 0.109). Conclusions: CE may be involved in the failure of embryo implantation and reduced clinical pregnancy outcome in patients with RIF.http://www.sciencedirect.com/science/article/pii/S1028455922002777Chronic endometritisCD138Repeated implantation failure |
| spellingShingle | Yuye Li Yanhong Xu Shuyi Yu Shenglai Lin Wanru Chen Ruochun Lian Lianghui Diao Haixiang Sun Lijun Ding Yong Zeng Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study Taiwanese Journal of Obstetrics & Gynecology Chronic endometritis CD138 Repeated implantation failure |
| title | Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study |
| title_full | Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study |
| title_fullStr | Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study |
| title_full_unstemmed | Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study |
| title_short | Chronic endometritis impairs embryo implantation in patients with repeated implantation failure: A retrospective study |
| title_sort | chronic endometritis impairs embryo implantation in patients with repeated implantation failure a retrospective study |
| topic | Chronic endometritis CD138 Repeated implantation failure |
| url | http://www.sciencedirect.com/science/article/pii/S1028455922002777 |
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