Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities

Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities

Abstract CINAC-patients present renal proximal tubular cell lysosomal lesions which are also observed in patients experiencing calcineurin inhibitor (CNI) nephrotoxicity, suggesting that CINAC is a toxin-induced nephropathy. An alternative hypothesis advocates chronic dehydration as a major etiologi...

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Bibliographic Details
Main Authors: Gerd Schreurs, Stuart Maudsley, Cynthia Nast, Marleen Praet, Sylvina Da Silva Fernandes, Peter Boor, Patrick D’Haese, Marc E. De Broe, Benjamin A. Vervaet
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43567-z

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