Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder
Alzheimer’s disease (AD) is caused by excessive oxidative damage and aging. The objective of this study was to investigate the anti-dementia effect of LCP fruit powder on amyloid β (Aβ)-induced Alzheimer’s mice. The composition of LCP essential oil was determined by gas chromatography/mass spectrome...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/18/5709 |
| _version_ | 1797517939920863232 |
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| author | Kuan-Tseng Lee Chen-Yeon Chu Shen-Shih Chiang |
| author_facet | Kuan-Tseng Lee Chen-Yeon Chu Shen-Shih Chiang |
| author_sort | Kuan-Tseng Lee |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is caused by excessive oxidative damage and aging. The objective of this study was to investigate the anti-dementia effect of LCP fruit powder on amyloid β (Aβ)-induced Alzheimer’s mice. The composition of LCP essential oil was determined by gas chromatography/mass spectrometry. In addition, the water maze was used to evaluate the learning and memorizing abilities of the mice. The concentrations of malondialdehyde (MDA), protein carbonyl, phosphorylated τ-protein, and the deposition of Aβ plaques in mouse brains were also assessed. The results showed that the main components of essential oils in LCP and d-limonene, neral, and geranial contents were 14.15%, 30.94%, and 31.74%, respectively. Furthermore, oral administration with different dosages of LCP significantly decreased the escape time (21.25~33.62 s) and distance (3.23~5.07 m) in the reference memory test, and increased the duration time (26.14~28.90 s) and crossing frequency (7.00~7.88 times) in the target zone of probe test (<i>p</i> < 0.05). LCP also inhibited the contents of MDA and the phosphor-τ-protein from oxidative stress, reduced the brain atrophy by about 3~8%, and decreased the percentage of Aβ plaques from 0.44 to 0.05%. Finally, it was observed that the minimum dosage of LCP fruit powder (LLCP, 30.2 mg/day) could prevent oxidative stress induced by Aβ and subsequently facilitate memory and learning deficits in Aβ-induced neurotoxicity and cognitively impaired mice. |
| first_indexed | 2024-03-10T07:23:13Z |
| format | Article |
| id | doaj.art-6be59174c3d044b19d023b8353156a07 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T07:23:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6be59174c3d044b19d023b8353156a072023-11-22T14:27:18ZengMDPI AGMolecules1420-30492021-09-012618570910.3390/molecules26185709Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon PowderKuan-Tseng Lee0Chen-Yeon Chu1Shen-Shih Chiang2Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung 40227, TaiwanInstitute of Green Products, Feng Chia University, Taichung 40724, TaiwanDepartment of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung 40227, TaiwanAlzheimer’s disease (AD) is caused by excessive oxidative damage and aging. The objective of this study was to investigate the anti-dementia effect of LCP fruit powder on amyloid β (Aβ)-induced Alzheimer’s mice. The composition of LCP essential oil was determined by gas chromatography/mass spectrometry. In addition, the water maze was used to evaluate the learning and memorizing abilities of the mice. The concentrations of malondialdehyde (MDA), protein carbonyl, phosphorylated τ-protein, and the deposition of Aβ plaques in mouse brains were also assessed. The results showed that the main components of essential oils in LCP and d-limonene, neral, and geranial contents were 14.15%, 30.94%, and 31.74%, respectively. Furthermore, oral administration with different dosages of LCP significantly decreased the escape time (21.25~33.62 s) and distance (3.23~5.07 m) in the reference memory test, and increased the duration time (26.14~28.90 s) and crossing frequency (7.00~7.88 times) in the target zone of probe test (<i>p</i> < 0.05). LCP also inhibited the contents of MDA and the phosphor-τ-protein from oxidative stress, reduced the brain atrophy by about 3~8%, and decreased the percentage of Aβ plaques from 0.44 to 0.05%. Finally, it was observed that the minimum dosage of LCP fruit powder (LLCP, 30.2 mg/day) could prevent oxidative stress induced by Aβ and subsequently facilitate memory and learning deficits in Aβ-induced neurotoxicity and cognitively impaired mice.https://www.mdpi.com/1420-3049/26/18/5709Alzheimer’s diseaseamyloid β protein<i>Litsea cubeba</i> Persoonneurotoxicitycognitive impairment |
| spellingShingle | Kuan-Tseng Lee Chen-Yeon Chu Shen-Shih Chiang Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder Molecules Alzheimer’s disease amyloid β protein <i>Litsea cubeba</i> Persoon neurotoxicity cognitive impairment |
| title | Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder |
| title_full | Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder |
| title_fullStr | Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder |
| title_full_unstemmed | Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder |
| title_short | Ameliorating Effect on Aβ-Induced Alzheimer’s Mice by <i>Litsea cubeba</i> Persoon Powder |
| title_sort | ameliorating effect on aβ induced alzheimer s mice by i litsea cubeba i persoon powder |
| topic | Alzheimer’s disease amyloid β protein <i>Litsea cubeba</i> Persoon neurotoxicity cognitive impairment |
| url | https://www.mdpi.com/1420-3049/26/18/5709 |
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