Mechanisms of esophageal cancer metastasis and treatment progress
Esophageal cancer is a prevalent tumor of the digestive tract worldwide. The detection rate of early-stage esophageal cancer is very low, and most patients are diagnosed with metastasis. Metastasis of esophageal cancer mainly includes direct diffusion metastasis, hematogenous metastasis, and lymphat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206504/full |
| _version_ | 1797809087712329728 |
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| author | Yusheng Wang Wei Yang Qianyun Wang Yong Zhou |
| author_facet | Yusheng Wang Wei Yang Qianyun Wang Yong Zhou |
| author_sort | Yusheng Wang |
| collection | DOAJ |
| description | Esophageal cancer is a prevalent tumor of the digestive tract worldwide. The detection rate of early-stage esophageal cancer is very low, and most patients are diagnosed with metastasis. Metastasis of esophageal cancer mainly includes direct diffusion metastasis, hematogenous metastasis, and lymphatic metastasis. This article reviews the metabolic process of esophageal cancer metastasis and the mechanisms by which M2 macrophages, CAF, regulatory T cells, and their released cytokines, including chemokines, interleukins, and growth factors, form an immune barrier to the anti-tumor immune response mediated by CD8+ T cells, impeding their ability to kill tumor cells during tumor immune escape. The effect of Ferroptosis on the metastasis of esophageal cancer is briefly mentioned. Moreover, the paper also summarizes common drugs and research directions in chemotherapy, immunotherapy, and targeted therapy for advanced metastatic esophageal cancer. This review aims to serve as a foundation for further investigations into the mechanism and management of esophageal cancer metastasis. |
| first_indexed | 2024-03-13T06:47:20Z |
| format | Article |
| id | doaj.art-6be74a532d5e4f94bb29a4990edfba9d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-13T06:47:20Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6be74a532d5e4f94bb29a4990edfba9d2023-06-08T05:07:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-06-011410.3389/fimmu.2023.12065041206504Mechanisms of esophageal cancer metastasis and treatment progressYusheng Wang0Wei Yang1Qianyun Wang2Yong Zhou3Department of Thoracic Surgery, The First People’s Hospital of Changzhou, Changzhou, Jiangsu, ChinaDepartment of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, ChinaDepartment of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, ChinaDepartment of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu, ChinaEsophageal cancer is a prevalent tumor of the digestive tract worldwide. The detection rate of early-stage esophageal cancer is very low, and most patients are diagnosed with metastasis. Metastasis of esophageal cancer mainly includes direct diffusion metastasis, hematogenous metastasis, and lymphatic metastasis. This article reviews the metabolic process of esophageal cancer metastasis and the mechanisms by which M2 macrophages, CAF, regulatory T cells, and their released cytokines, including chemokines, interleukins, and growth factors, form an immune barrier to the anti-tumor immune response mediated by CD8+ T cells, impeding their ability to kill tumor cells during tumor immune escape. The effect of Ferroptosis on the metastasis of esophageal cancer is briefly mentioned. Moreover, the paper also summarizes common drugs and research directions in chemotherapy, immunotherapy, and targeted therapy for advanced metastatic esophageal cancer. This review aims to serve as a foundation for further investigations into the mechanism and management of esophageal cancer metastasis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206504/fullmetastasisesophageal canceranatomical mechanismmolecular mechanismchemotherapyimmunotherapy |
| spellingShingle | Yusheng Wang Wei Yang Qianyun Wang Yong Zhou Mechanisms of esophageal cancer metastasis and treatment progress Frontiers in Immunology metastasis esophageal cancer anatomical mechanism molecular mechanism chemotherapy immunotherapy |
| title | Mechanisms of esophageal cancer metastasis and treatment progress |
| title_full | Mechanisms of esophageal cancer metastasis and treatment progress |
| title_fullStr | Mechanisms of esophageal cancer metastasis and treatment progress |
| title_full_unstemmed | Mechanisms of esophageal cancer metastasis and treatment progress |
| title_short | Mechanisms of esophageal cancer metastasis and treatment progress |
| title_sort | mechanisms of esophageal cancer metastasis and treatment progress |
| topic | metastasis esophageal cancer anatomical mechanism molecular mechanism chemotherapy immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206504/full |
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