Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin

Abstract Type II polyketide synthases (PKSs) normally synthesize polycyclic aromatic compounds in nature, and the potential to elaborate further diverse skeletons was recently revealed by the discovery of a polyene subgroup. Here, we show a type II PKS machinery for the biosynthesis of a five-member...

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Bibliographic Details
Main Authors: Genki Hibi, Taro Shiraishi, Tatsuki Umemura, Kenji Nemoto, Yusuke Ogura, Makoto Nishiyama, Tomohisa Kuzuyama
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43731-z