Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells
Patients with obstructive sleep apnea (OSA) experience repetitive episodes of desaturation and resaturation of blood oxygen (known as intermittent hypoxia or IH), during sleep. We showed previously that IH induced excessive proliferation of rat vascular smooth muscle cells through upregulation of me...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-05-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.12430 |
| _version_ | 1827987720539996160 |
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| author | Yoji Kyotani Asako Itaya‐Hironaka Akiyo Yamauchi Sumiyo Sakuramoto‐Tsuchida Mai Makino Shin Takasawa Masanori Yoshizumi |
| author_facet | Yoji Kyotani Asako Itaya‐Hironaka Akiyo Yamauchi Sumiyo Sakuramoto‐Tsuchida Mai Makino Shin Takasawa Masanori Yoshizumi |
| author_sort | Yoji Kyotani |
| collection | DOAJ |
| description | Patients with obstructive sleep apnea (OSA) experience repetitive episodes of desaturation and resaturation of blood oxygen (known as intermittent hypoxia or IH), during sleep. We showed previously that IH induced excessive proliferation of rat vascular smooth muscle cells through upregulation of members of the epidermal growth factor family, especially epiregulin (EREG), and the erbB2 receptor. In this study, we exposed human coronary artery smooth muscle cells to IH and found that IH significantly increased the expression of EREG. IH increased the production of interleukin‐6 (IL‐6) in smooth muscle cells, and the addition of IL‐6 induced EREG expression. Small interfering RNA for IL‐6 or IL‐6 receptor attenuated the IH‐induced increase in EREG. IL‐6 may play a pivotal role in EREG upregulation by IH and consequently OSA‐related atherosclerosis. |
| first_indexed | 2024-04-09T23:52:30Z |
| format | Article |
| id | doaj.art-6beaa8a64bf04daebb6eb0eaccca6605 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-04-09T23:52:30Z |
| publishDate | 2018-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-6beaa8a64bf04daebb6eb0eaccca66052023-03-17T06:46:13ZengWileyFEBS Open Bio2211-54632018-05-018586887610.1002/2211-5463.12430Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cellsYoji Kyotani0Asako Itaya‐Hironaka1Akiyo Yamauchi2Sumiyo Sakuramoto‐Tsuchida3Mai Makino4Shin Takasawa5Masanori Yoshizumi6Department of Pharmacology Nara Medical University Kashihara JapanDepartment of Biochemistry Nara Medical University Kashihara JapanDepartment of Biochemistry Nara Medical University Kashihara JapanDepartment of Biochemistry Nara Medical University Kashihara JapanDepartment of Biochemistry Nara Medical University Kashihara JapanDepartment of Biochemistry Nara Medical University Kashihara JapanDepartment of Pharmacology Nara Medical University Kashihara JapanPatients with obstructive sleep apnea (OSA) experience repetitive episodes of desaturation and resaturation of blood oxygen (known as intermittent hypoxia or IH), during sleep. We showed previously that IH induced excessive proliferation of rat vascular smooth muscle cells through upregulation of members of the epidermal growth factor family, especially epiregulin (EREG), and the erbB2 receptor. In this study, we exposed human coronary artery smooth muscle cells to IH and found that IH significantly increased the expression of EREG. IH increased the production of interleukin‐6 (IL‐6) in smooth muscle cells, and the addition of IL‐6 induced EREG expression. Small interfering RNA for IL‐6 or IL‐6 receptor attenuated the IH‐induced increase in EREG. IL‐6 may play a pivotal role in EREG upregulation by IH and consequently OSA‐related atherosclerosis.https://doi.org/10.1002/2211-5463.12430epiregulininterleukin‐6intermittent hypoxia |
| spellingShingle | Yoji Kyotani Asako Itaya‐Hironaka Akiyo Yamauchi Sumiyo Sakuramoto‐Tsuchida Mai Makino Shin Takasawa Masanori Yoshizumi Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells FEBS Open Bio epiregulin interleukin‐6 intermittent hypoxia |
| title | Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells |
| title_full | Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells |
| title_fullStr | Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells |
| title_full_unstemmed | Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells |
| title_short | Intermittent hypoxia‐induced epiregulin expression by IL‐6 production in human coronary artery smooth muscle cells |
| title_sort | intermittent hypoxia induced epiregulin expression by il 6 production in human coronary artery smooth muscle cells |
| topic | epiregulin interleukin‐6 intermittent hypoxia |
| url | https://doi.org/10.1002/2211-5463.12430 |
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