Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years

Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years

Abstract Background In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to dementia-related biomarkers should be explored. Ther...

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Bibliographic Details
Main Authors: Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Hermann Brenner
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Polygenic risk scores
Blood-biomarkers
Online Access:https://doi.org/10.1186/s13195-023-01277-8

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