Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a hallmark of the severe premature ageing syndrome, Hutchinson-Gilford progeria. Progerin elicits toxic effects in cells, lea...

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Bibliographic Details
Main Authors: V. Cenni, C. Capanni, M. Columbaro, M. Ortolani, M.R. D'Apice, G. Novelli, M. Fini, S. Marmiroli, E. Scarano, N.M. Maraldi, S. Squarzoni, S. Prencipe, G. Lattanzi
Format: Article
Language:English
Published: PAGEPress Publications 2011-10-01
Series:European Journal of Histochemistry
Subjects:
prelamin A, autophagy, protein degradation, laminopathies, progeria, Rapamycinprelamin A, autophagy, protein degradation, laminopathies, progeria, Rapamycin
Online Access:http://www.ejh.it/index.php/ejh/article/view/1895

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