Ferroptosis and its role in skeletal muscle diseases
Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products, which regulates physiological and pathological processes in numerous organs and tissues. A growing body of research suggests that ferroptosis is a key causative factor in a variety of skeletal muscle diseases,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1051866/full |
| _version_ | 1811192797243375616 |
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| author | Ying Wang Zepeng Zhang Weikai Jiao Yanyan Wang Xiuge Wang Yunyun Zhao Xuechun Fan Lulu Tian Xiangyan Li Jia Mi |
| author_facet | Ying Wang Zepeng Zhang Weikai Jiao Yanyan Wang Xiuge Wang Yunyun Zhao Xuechun Fan Lulu Tian Xiangyan Li Jia Mi |
| author_sort | Ying Wang |
| collection | DOAJ |
| description | Ferroptosis is characterized by the accumulation of iron and lipid peroxidation products, which regulates physiological and pathological processes in numerous organs and tissues. A growing body of research suggests that ferroptosis is a key causative factor in a variety of skeletal muscle diseases, including sarcopenia, rhabdomyolysis, rhabdomyosarcoma, and exhaustive exercise-induced fatigue. However, the relationship between ferroptosis and various skeletal muscle diseases has not been investigated systematically. This review’s objective is to provide a comprehensive summary of the mechanisms and signaling factors that regulate ferroptosis, including lipid peroxidation, iron/heme, amino acid metabolism, and autophagy. In addition, we tease out the role of ferroptosis in the progression of different skeletal muscle diseases and ferroptosis as a potential target for the treatment of multiple skeletal muscle diseases. This review can provide valuable reference for the research on the pathogenesis of skeletal muscle diseases, as well as for clinical prevention and treatment. |
| first_indexed | 2024-04-11T23:57:30Z |
| format | Article |
| id | doaj.art-6bef121aaf3444e88b999ca9fa193f3a |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-04-11T23:57:30Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-6bef121aaf3444e88b999ca9fa193f3a2022-12-22T03:56:19ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-11-01910.3389/fmolb.2022.10518661051866Ferroptosis and its role in skeletal muscle diseasesYing Wang0Zepeng Zhang1Weikai Jiao2Yanyan Wang3Xiuge Wang4Yunyun Zhao5Xuechun Fan6Lulu Tian7Xiangyan Li8Jia Mi9College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaResearch Center of Traditional Chinese Medicine, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaSchool of Life Sciences, Zhejiang Chinese Medical University, Hangzhou, ChinaNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaFerroptosis is characterized by the accumulation of iron and lipid peroxidation products, which regulates physiological and pathological processes in numerous organs and tissues. A growing body of research suggests that ferroptosis is a key causative factor in a variety of skeletal muscle diseases, including sarcopenia, rhabdomyolysis, rhabdomyosarcoma, and exhaustive exercise-induced fatigue. However, the relationship between ferroptosis and various skeletal muscle diseases has not been investigated systematically. This review’s objective is to provide a comprehensive summary of the mechanisms and signaling factors that regulate ferroptosis, including lipid peroxidation, iron/heme, amino acid metabolism, and autophagy. In addition, we tease out the role of ferroptosis in the progression of different skeletal muscle diseases and ferroptosis as a potential target for the treatment of multiple skeletal muscle diseases. This review can provide valuable reference for the research on the pathogenesis of skeletal muscle diseases, as well as for clinical prevention and treatment.https://www.frontiersin.org/articles/10.3389/fmolb.2022.1051866/fullferroptosismechanismsarcopeniarhabdomyolysisrhabdomyosarcomafatigue |
| spellingShingle | Ying Wang Zepeng Zhang Weikai Jiao Yanyan Wang Xiuge Wang Yunyun Zhao Xuechun Fan Lulu Tian Xiangyan Li Jia Mi Ferroptosis and its role in skeletal muscle diseases Frontiers in Molecular Biosciences ferroptosis mechanism sarcopenia rhabdomyolysis rhabdomyosarcoma fatigue |
| title | Ferroptosis and its role in skeletal muscle diseases |
| title_full | Ferroptosis and its role in skeletal muscle diseases |
| title_fullStr | Ferroptosis and its role in skeletal muscle diseases |
| title_full_unstemmed | Ferroptosis and its role in skeletal muscle diseases |
| title_short | Ferroptosis and its role in skeletal muscle diseases |
| title_sort | ferroptosis and its role in skeletal muscle diseases |
| topic | ferroptosis mechanism sarcopenia rhabdomyolysis rhabdomyosarcoma fatigue |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.1051866/full |
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