Nuclear Tau and Its Potential Role in Alzheimer’s Disease
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and pathology in the context of the microtubules, even th...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-273X/6/1/9 |
| _version_ | 1818960681632792576 |
|---|---|
| author | Mahmoud Bukar Maina Youssra K. Al-Hilaly Louise C. Serpell |
| author_facet | Mahmoud Bukar Maina Youssra K. Al-Hilaly Louise C. Serpell |
| author_sort | Mahmoud Bukar Maina |
| collection | DOAJ |
| description | Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and pathology in the context of the microtubules, even though, for over three decades, tau has been localised in the nucleus and the nucleolus. Its nuclear and nucleolar localisation had stimulated many questions regarding its role in these compartments. Data from cell culture, mouse brain, and the human brain suggests that nuclear tau could be essential for genome defense against cellular distress. However, its nature of translocation to the nucleus, its nuclear conformation and interaction with the DNA and other nuclear proteins highly suggest it could play multiple roles in the nucleus. To find efficient tau-based therapies, there is a need to understand more about the functional relevance of the varied cellular distribution of tau, identify whether specific tau transcripts or isoforms could predict tau’s localisation and function and how they are altered in diseases like AD. Here, we explore the cellular distribution of tau, its nuclear localisation and function and its possible involvement in neurodegeneration. |
| first_indexed | 2024-12-20T12:01:24Z |
| format | Article |
| id | doaj.art-6bf0aebdad5740df85b67c91c5f150a5 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-20T12:01:24Z |
| publishDate | 2016-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6bf0aebdad5740df85b67c91c5f150a52022-12-21T19:41:31ZengMDPI AGBiomolecules2218-273X2016-01-0161910.3390/biom6010009biom6010009Nuclear Tau and Its Potential Role in Alzheimer’s DiseaseMahmoud Bukar Maina0Youssra K. Al-Hilaly1Louise C. Serpell2School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, East Sussex, UKSchool of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, East Sussex, UKSchool of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, East Sussex, UKTau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD). For nearly four decades, research efforts have focused more on tau’s role in physiology and pathology in the context of the microtubules, even though, for over three decades, tau has been localised in the nucleus and the nucleolus. Its nuclear and nucleolar localisation had stimulated many questions regarding its role in these compartments. Data from cell culture, mouse brain, and the human brain suggests that nuclear tau could be essential for genome defense against cellular distress. However, its nature of translocation to the nucleus, its nuclear conformation and interaction with the DNA and other nuclear proteins highly suggest it could play multiple roles in the nucleus. To find efficient tau-based therapies, there is a need to understand more about the functional relevance of the varied cellular distribution of tau, identify whether specific tau transcripts or isoforms could predict tau’s localisation and function and how they are altered in diseases like AD. Here, we explore the cellular distribution of tau, its nuclear localisation and function and its possible involvement in neurodegeneration.http://www.mdpi.com/2218-273X/6/1/9taunucleusnucleolusAlzheimer’s diseasepaired helical filamentneurofibrillary tangles |
| spellingShingle | Mahmoud Bukar Maina Youssra K. Al-Hilaly Louise C. Serpell Nuclear Tau and Its Potential Role in Alzheimer’s Disease Biomolecules tau nucleus nucleolus Alzheimer’s disease paired helical filament neurofibrillary tangles |
| title | Nuclear Tau and Its Potential Role in Alzheimer’s Disease |
| title_full | Nuclear Tau and Its Potential Role in Alzheimer’s Disease |
| title_fullStr | Nuclear Tau and Its Potential Role in Alzheimer’s Disease |
| title_full_unstemmed | Nuclear Tau and Its Potential Role in Alzheimer’s Disease |
| title_short | Nuclear Tau and Its Potential Role in Alzheimer’s Disease |
| title_sort | nuclear tau and its potential role in alzheimer s disease |
| topic | tau nucleus nucleolus Alzheimer’s disease paired helical filament neurofibrillary tangles |
| url | http://www.mdpi.com/2218-273X/6/1/9 |
| work_keys_str_mv | AT mahmoudbukarmaina nucleartauanditspotentialroleinalzheimersdisease AT youssrakalhilaly nucleartauanditspotentialroleinalzheimersdisease AT louisecserpell nucleartauanditspotentialroleinalzheimersdisease |