PINK1 Protects Against Gentamicin-Induced Sensory Hair Cell Damage: Possible Relation to Induction of Autophagy and Inhibition of p53 Signal Pathway

PINK1 Protects Against Gentamicin-Induced Sensory Hair Cell Damage: Possible Relation to Induction of Autophagy and Inhibition of p53 Signal Pathway

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair cell (HC) damage in vitro. The formation of park...

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Bibliographic Details
Main Authors: Qianqian Yang, Yiwei Zhou, Haiyan Yin, Hongrui Li, Meijuan Zhou, Gaoying Sun, Zhixin Cao, Rongjun Man, Haibo Wang, Jianfeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)
gentamicin (GM)
ROS
autophagy
p53
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00403/full

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