Effects of steroids on bone mineral content in women with bronchial asthma
The effects of corticosteroids on bone mass in patients with bronchial asthma (BA) are still controversial. To elucidate whether steroid administration may influence bone mineral content (BMC) and bone mineral density (BMD) in women with BA, a longitudinal study was designed for adult female asthmat...
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| Format: | Article |
| Language: | English |
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Elsevier
1998-01-01
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| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015315471 |
| _version_ | 1818195325178871808 |
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| author | Yoshihiro Nishimura Hiroyuki Nakata Tomohiko Shirotani Yoshikazu Kotani Hitoshi Maeda Mitsuhiro Yokoyama |
| author_facet | Yoshihiro Nishimura Hiroyuki Nakata Tomohiko Shirotani Yoshikazu Kotani Hitoshi Maeda Mitsuhiro Yokoyama |
| author_sort | Yoshihiro Nishimura |
| collection | DOAJ |
| description | The effects of corticosteroids on bone mass in patients with bronchial asthma (BA) are still controversial. To elucidate whether steroid administration may influence bone mineral content (BMC) and bone mineral density (BMD) in women with BA, a longitudinal study was designed for adult female asthmatics receiving long-term steroid therapy. We measured whole body BMC and lumbar BMD by dual energy X-ray absorptiometry in 23 women with BA and compared the results with those from 17 age-matched controls. Both patient and control groups were followed up for at least 1 year (mean (± SD) observation period 94 ± 33 weeks). We divided the asthmatic patients into two groups on the basis of the mode of steroid administration: (i) group A consisted of 10 patients with low dose oral steroid administration (prednisolone 5–10 mg daily); and (ii) group B consisted of 13 patients with low dose beclomethasone dipropionate (BDP) inhalation therapy (BDP 400–800 mg daily). There were no significant differences in both baseline values and changes of BMC and BMD among the three groups. These results demonstrate that asthmatic patients show normal bone mass and that both low dose steroid administration and BDP inhalation do not significantly affect BMC in patients with BA over the period studied. We suggest that appropriate steroid use does not augment bone mineral loss in asthmatics. |
| first_indexed | 2024-12-12T01:16:23Z |
| format | Article |
| id | doaj.art-6bf675b941664d07b076376fb410c16a |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-12T01:16:23Z |
| publishDate | 1998-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-6bf675b941664d07b076376fb410c16a2022-12-22T00:43:19ZengElsevierAllergology International1323-89301998-01-0147211712210.2332/allergolint.47.117Effects of steroids on bone mineral content in women with bronchial asthmaYoshihiro Nishimura0Hiroyuki Nakata1Tomohiko Shirotani2Yoshikazu Kotani3Hitoshi Maeda4Mitsuhiro Yokoyama5The First Department of Internal Medicine, Kobe University School of Medicine, Kobe, JapanThe Department of Respiratory Disease, Takatsuki General Hospital, Takatsuki, JapanThe Department of Respiratory Disease, Takatsuki General Hospital, Takatsuki, JapanThe First Department of Internal Medicine, Kobe University School of Medicine, Kobe, JapanThe First Department of Internal Medicine, Kobe University School of Medicine, Kobe, JapanThe First Department of Internal Medicine, Kobe University School of Medicine, Kobe, JapanThe effects of corticosteroids on bone mass in patients with bronchial asthma (BA) are still controversial. To elucidate whether steroid administration may influence bone mineral content (BMC) and bone mineral density (BMD) in women with BA, a longitudinal study was designed for adult female asthmatics receiving long-term steroid therapy. We measured whole body BMC and lumbar BMD by dual energy X-ray absorptiometry in 23 women with BA and compared the results with those from 17 age-matched controls. Both patient and control groups were followed up for at least 1 year (mean (± SD) observation period 94 ± 33 weeks). We divided the asthmatic patients into two groups on the basis of the mode of steroid administration: (i) group A consisted of 10 patients with low dose oral steroid administration (prednisolone 5–10 mg daily); and (ii) group B consisted of 13 patients with low dose beclomethasone dipropionate (BDP) inhalation therapy (BDP 400–800 mg daily). There were no significant differences in both baseline values and changes of BMC and BMD among the three groups. These results demonstrate that asthmatic patients show normal bone mass and that both low dose steroid administration and BDP inhalation do not significantly affect BMC in patients with BA over the period studied. We suggest that appropriate steroid use does not augment bone mineral loss in asthmatics.http://www.sciencedirect.com/science/article/pii/S1323893015315471beclomethasone dipropionatebody compositionosteoporosispulmonary function |
| spellingShingle | Yoshihiro Nishimura Hiroyuki Nakata Tomohiko Shirotani Yoshikazu Kotani Hitoshi Maeda Mitsuhiro Yokoyama Effects of steroids on bone mineral content in women with bronchial asthma Allergology International beclomethasone dipropionate body composition osteoporosis pulmonary function |
| title | Effects of steroids on bone mineral content in women with bronchial asthma |
| title_full | Effects of steroids on bone mineral content in women with bronchial asthma |
| title_fullStr | Effects of steroids on bone mineral content in women with bronchial asthma |
| title_full_unstemmed | Effects of steroids on bone mineral content in women with bronchial asthma |
| title_short | Effects of steroids on bone mineral content in women with bronchial asthma |
| title_sort | effects of steroids on bone mineral content in women with bronchial asthma |
| topic | beclomethasone dipropionate body composition osteoporosis pulmonary function |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015315471 |
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