Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection
Background: Distributions of serum pepsinogen (PG) values were assessed in Helicobacter pylori-infected and non-infected junior high school students (aged 12–15 years) in Japan. Methods: All junior high school students (1,225 in total) in Sasayama city, who were basically healthy, were asked to prov...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2020-01-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/30/1/30_JE20180119/_pdf |
| _version_ | 1819144271248228352 |
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| author | Masumi Okuda Yingsong Lin Katsuhiro Mabe Mototsugu Kato Takako Osaki Ryosuke Miyamoto Akihisa Okumura Shigeru Kamiya Shogo Kikuchi |
| author_facet | Masumi Okuda Yingsong Lin Katsuhiro Mabe Mototsugu Kato Takako Osaki Ryosuke Miyamoto Akihisa Okumura Shigeru Kamiya Shogo Kikuchi |
| author_sort | Masumi Okuda |
| collection | DOAJ |
| description | Background: Distributions of serum pepsinogen (PG) values were assessed in Helicobacter pylori-infected and non-infected junior high school students (aged 12–15 years) in Japan. Methods: All junior high school students (1,225 in total) in Sasayama city, who were basically healthy, were asked to provide urine and serum samples, which were used to measure urine and serum H. pylori antibodies using ELISA kits and PG values. The subjects, whose urine and serum antibodies were both positive, were considered H. pylori infected. Results: Of the 187 subjects who provided urine and blood samples, 8 were infected, 4 had discrepant results, 4 had negative serum antibody titers no less than 3.0 U/ml, and 171 were non-infected. In the H. pylori non-infected subjects, the median PG I and PG II values and PG I to PG II ratio (PG I/II) were 40.8 ng/mL, 9.5 ng/mL, and 4.4, respectively, whereas in the infected subjects, these values were 55.4 ng/mL, 17.0 ng/mL, and 3.3, respectively (each P < 0.01). In the non-infected subjects, PG I and PG II were significantly higher in males than in females (P < 0.01). Conclusions: The PG I and PG II values were higher, and the PG I/II was lower in H. pylori infected students than in non-infected students. In H. pylori non-infected students, males showed higher PG I and PG II values than females. The distributions of PG values in junior high school students differed from those in adults. |
| first_indexed | 2024-12-22T12:39:29Z |
| format | Article |
| id | doaj.art-6bf8a5dd4cb14ca8944641d7f7cc3bdc |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-22T12:39:29Z |
| publishDate | 2020-01-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-6bf8a5dd4cb14ca8944641d7f7cc3bdc2022-12-21T18:25:28ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922020-01-01301303610.2188/jea.JE20180119Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori InfectionMasumi Okuda0Yingsong Lin1Katsuhiro Mabe2Mototsugu Kato3Takako Osaki4Ryosuke Miyamoto5Akihisa Okumura6Shigeru Kamiya7Shogo Kikuchi8Department of Pediatrics, Aichi Medical University School of Medicine, Aichi, JapanDepartment of Public Health, Aichi Medical University, School of Medicine, Aichi, JapanDepartment of Cancer Preventive Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, JapanDivision of Endoscopy, Hokkaido University Hospital, Hokkaido, JapanDepartment of Infectious Diseases, Kyorin University School of Medicine, Tokyo, JapanDepartment of Pediatrics, Aichi Medical University School of Medicine, Aichi, JapanDepartment of Pediatrics, Aichi Medical University School of Medicine, Aichi, JapanDepartment of Infectious Diseases, Kyorin University School of Medicine, Tokyo, JapanDepartment of Public Health, Aichi Medical University, School of Medicine, Aichi, JapanBackground: Distributions of serum pepsinogen (PG) values were assessed in Helicobacter pylori-infected and non-infected junior high school students (aged 12–15 years) in Japan. Methods: All junior high school students (1,225 in total) in Sasayama city, who were basically healthy, were asked to provide urine and serum samples, which were used to measure urine and serum H. pylori antibodies using ELISA kits and PG values. The subjects, whose urine and serum antibodies were both positive, were considered H. pylori infected. Results: Of the 187 subjects who provided urine and blood samples, 8 were infected, 4 had discrepant results, 4 had negative serum antibody titers no less than 3.0 U/ml, and 171 were non-infected. In the H. pylori non-infected subjects, the median PG I and PG II values and PG I to PG II ratio (PG I/II) were 40.8 ng/mL, 9.5 ng/mL, and 4.4, respectively, whereas in the infected subjects, these values were 55.4 ng/mL, 17.0 ng/mL, and 3.3, respectively (each P < 0.01). In the non-infected subjects, PG I and PG II were significantly higher in males than in females (P < 0.01). Conclusions: The PG I and PG II values were higher, and the PG I/II was lower in H. pylori infected students than in non-infected students. In H. pylori non-infected students, males showed higher PG I and PG II values than females. The distributions of PG values in junior high school students differed from those in adults.https://www.jstage.jst.go.jp/article/jea/30/1/30_JE20180119/_pdfstudentsurine antibodyserum antibodyserum pepsinogen |
| spellingShingle | Masumi Okuda Yingsong Lin Katsuhiro Mabe Mototsugu Kato Takako Osaki Ryosuke Miyamoto Akihisa Okumura Shigeru Kamiya Shogo Kikuchi Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection Journal of Epidemiology students urine antibody serum antibody serum pepsinogen |
| title | Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection |
| title_full | Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection |
| title_fullStr | Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection |
| title_full_unstemmed | Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection |
| title_short | Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection |
| title_sort | serum pepsinogen values in japanese junior high school students with reference to helicobacter pylori infection |
| topic | students urine antibody serum antibody serum pepsinogen |
| url | https://www.jstage.jst.go.jp/article/jea/30/1/30_JE20180119/_pdf |
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