Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The human mitochondrial genome includes only 13 coding genes while nuclear-encoded genes account for 99% of proteins responsible for mitochondrial morphology, redox regulation, and energetics. Mitochondrial pathogenesis occurs in HIV patients and genetically, mitochondrial DNA haplogroups with presu...

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Bibliographic Details
Main Authors: Sher L Hendrickson, James A Lautenberger, Leslie Wei Chinn, Michael Malasky, Efe Sezgin, Lawrence A Kingsley, James J Goedert, Gregory D Kirk, Edward D Gomperts, Susan P Buchbinder, Jennifer L Troyer, Stephen J O'Brien
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2943476?pdf=render

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