The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome
ABSTRACT: Objective: Recurrent Cushing disease (CD) is a rare complication that occurs in patients who have undergone bilateral adrenalectomy (BLA). We report a case of recurrent CD in a patient with Nelson syndrome and adrenalectomy due to remnant adrenal tissue, and a novel treatment strategy usi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | AACE Clinical Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2376060520300705 |
| _version_ | 1819020804770234368 |
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| author | Alexandra N. Martirossian, MD Rojymon Jacob, MD Kristen O. Riley, MD John R. Porterfield, MD Tom B. Vaughan, MD |
| author_facet | Alexandra N. Martirossian, MD Rojymon Jacob, MD Kristen O. Riley, MD John R. Porterfield, MD Tom B. Vaughan, MD |
| author_sort | Alexandra N. Martirossian, MD |
| collection | DOAJ |
| description | ABSTRACT: Objective: Recurrent Cushing disease (CD) is a rare complication that occurs in patients who have undergone bilateral adrenalectomy (BLA). We report a case of recurrent CD in a patient with Nelson syndrome and adrenalectomy due to remnant adrenal tissue, and a novel treatment strategy using stereotactic body radiation therapy (SBRT) to the adrenal glands. Methods: We report a case of recurrent CD in a woman with Nelson syndrome and adrenalectomy and describe her clinical course and management. We also include a literature review of CD management and adrenal radiation. Results: The patient had persistent pituitary CD despite pituitary surgery and radiosurgery and underwent BLA. She developed recurrent CD due to a remnant adrenal gland post adrenalectomy. She then underwent SBRT to both adrenal beds to treat the remnant adrenal tissue. Her serum cortisol dropped rapidly after adrenal radiation and she experienced minimal side effects. She has been in remission for over 2 years. Conclusion: This is the first reported case of recurrent CD in a patient post adrenalectomy that was successfully treated with SBRT to the remnant adrenal tissue. |
| first_indexed | 2024-12-21T03:57:02Z |
| format | Article |
| id | doaj.art-6bfe0906ad6f4ab4a65073c2fadbedc3 |
| institution | Directory Open Access Journal |
| issn | 2376-0605 |
| language | English |
| last_indexed | 2024-12-21T03:57:02Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AACE Clinical Case Reports |
| spelling | doaj.art-6bfe0906ad6f4ab4a65073c2fadbedc32022-12-21T19:16:48ZengElsevierAACE Clinical Case Reports2376-06052020-01-0161e33e36The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson SyndromeAlexandra N. Martirossian, MD0Rojymon Jacob, MD1Kristen O. Riley, MD2John R. Porterfield, MD3Tom B. Vaughan, MD4Address correspondence to Dr. Alexandra N. Martirossian, Department of Internal Medicine, University of Alabama at Birmingham, 1720 Second Avenue South, BDB 327, Birmingham, AL 35294-0012.; From Department of Internal Medicine, University of Alabama at BirminghamDepartment of Radiation Oncology, University of Alabama at BirminghamDepartment of Neurosurgery, University of Alabama at BirminghamDepartment of Surgery, University of Alabama at BirminghamDivision of Endocrinology, Diabetes, and Metabolism. University of Alabama at Birmingham, Birmingham, Alabama.ABSTRACT: Objective: Recurrent Cushing disease (CD) is a rare complication that occurs in patients who have undergone bilateral adrenalectomy (BLA). We report a case of recurrent CD in a patient with Nelson syndrome and adrenalectomy due to remnant adrenal tissue, and a novel treatment strategy using stereotactic body radiation therapy (SBRT) to the adrenal glands. Methods: We report a case of recurrent CD in a woman with Nelson syndrome and adrenalectomy and describe her clinical course and management. We also include a literature review of CD management and adrenal radiation. Results: The patient had persistent pituitary CD despite pituitary surgery and radiosurgery and underwent BLA. She developed recurrent CD due to a remnant adrenal gland post adrenalectomy. She then underwent SBRT to both adrenal beds to treat the remnant adrenal tissue. Her serum cortisol dropped rapidly after adrenal radiation and she experienced minimal side effects. She has been in remission for over 2 years. Conclusion: This is the first reported case of recurrent CD in a patient post adrenalectomy that was successfully treated with SBRT to the remnant adrenal tissue.http://www.sciencedirect.com/science/article/pii/S2376060520300705 |
| spellingShingle | Alexandra N. Martirossian, MD Rojymon Jacob, MD Kristen O. Riley, MD John R. Porterfield, MD Tom B. Vaughan, MD The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome AACE Clinical Case Reports |
| title | The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome |
| title_full | The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome |
| title_fullStr | The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome |
| title_full_unstemmed | The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome |
| title_short | The Novel Use of Stereotactic Radiotherapy for Remnant Adrenal Tissue in Nelson Syndrome |
| title_sort | novel use of stereotactic radiotherapy for remnant adrenal tissue in nelson syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2376060520300705 |
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