Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population
Abstract Widespread use of benzophenones (BPs), a group of environmental phenolic compounds, is suspected of interfering with human health. The association of prenatal exposure to benzophenone derivatives with birth outcomes including birth weight and length, head, arm and thoracic circumference, ab...
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| Format: | Article |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-35380-5 |
| _version_ | 1797806715089977344 |
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| author | Hakimeh Teiri Mohammad Reza Samaei Mansooreh Dehghani Abooalfazl Azhdarpoor Farzaneh Mohammadi Roya Kelishadi Yaghoub Hajizadeh |
| author_facet | Hakimeh Teiri Mohammad Reza Samaei Mansooreh Dehghani Abooalfazl Azhdarpoor Farzaneh Mohammadi Roya Kelishadi Yaghoub Hajizadeh |
| author_sort | Hakimeh Teiri |
| collection | DOAJ |
| description | Abstract Widespread use of benzophenones (BPs), a group of environmental phenolic compounds, is suspected of interfering with human health. The association of prenatal exposure to benzophenone derivatives with birth outcomes including birth weight and length, head, arm and thoracic circumference, abnormalities, corpulence index and anterior fontanelle diameter (AFD) was investigated. Mother-infant pairs of 166 within PERSIAN cohort population in Isfahan, Iran, in the 1st and 3rd trimesters of pregnancy were assessed. Four common benzophenone metabolites including 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-OH-BP) and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in maternal urine samples. The median concentration of 4-OH-BP, BP-3, BP-1 and BP-8 were 3.15, 16.98, 9.95 and 1.04 µg/g Cr, respectively. In the 1st trimester, 4-OH-BP showed a significant correlation with AFD in total infants, decreasing 0.034 cm AFD per a log unit increase of 4-OH-BP. Within the male neonates, 4-OH-BP in the 1st and BP-8 in the 3rd trimester were significantly associated with head circumference and AFD increase, respectively. Among female neonates in the 3rd trimester, increasing 4-OH-BP and BP-3 concentration was correlated with a decrease in birth weight and AFD, respectively. This study demonstrated that all the target BP derivatives can influence normal fetal growth at any age of the pregnancy, nevertheless, to support these findings further studies are needed in a large and different group population. |
| first_indexed | 2024-03-13T06:11:29Z |
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| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T06:11:29Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6bff1b9209b64de0bf5904e2a36e97352023-06-11T11:14:50ZengNature PortfolioScientific Reports2045-23222023-06-0113111310.1038/s41598-023-35380-5Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern populationHakimeh Teiri0Mohammad Reza Samaei1Mansooreh Dehghani2Abooalfazl Azhdarpoor3Farzaneh Mohammadi4Roya Kelishadi5Yaghoub Hajizadeh6Student Research Committee, Department of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, Faculty of Health, Isfahan University of Medical SciencesEnvironment Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan University of Medical SciencesEnvironment Research Center, Research Institute for Primordial Prevention of Non-Communicable Diseases, Isfahan University of Medical SciencesAbstract Widespread use of benzophenones (BPs), a group of environmental phenolic compounds, is suspected of interfering with human health. The association of prenatal exposure to benzophenone derivatives with birth outcomes including birth weight and length, head, arm and thoracic circumference, abnormalities, corpulence index and anterior fontanelle diameter (AFD) was investigated. Mother-infant pairs of 166 within PERSIAN cohort population in Isfahan, Iran, in the 1st and 3rd trimesters of pregnancy were assessed. Four common benzophenone metabolites including 2,4-dihydroxy benzophenone (BP-1), 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-OH-BP) and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in maternal urine samples. The median concentration of 4-OH-BP, BP-3, BP-1 and BP-8 were 3.15, 16.98, 9.95 and 1.04 µg/g Cr, respectively. In the 1st trimester, 4-OH-BP showed a significant correlation with AFD in total infants, decreasing 0.034 cm AFD per a log unit increase of 4-OH-BP. Within the male neonates, 4-OH-BP in the 1st and BP-8 in the 3rd trimester were significantly associated with head circumference and AFD increase, respectively. Among female neonates in the 3rd trimester, increasing 4-OH-BP and BP-3 concentration was correlated with a decrease in birth weight and AFD, respectively. This study demonstrated that all the target BP derivatives can influence normal fetal growth at any age of the pregnancy, nevertheless, to support these findings further studies are needed in a large and different group population.https://doi.org/10.1038/s41598-023-35380-5 |
| spellingShingle | Hakimeh Teiri Mohammad Reza Samaei Mansooreh Dehghani Abooalfazl Azhdarpoor Farzaneh Mohammadi Roya Kelishadi Yaghoub Hajizadeh Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population Scientific Reports |
| title | Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population |
| title_full | Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population |
| title_fullStr | Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population |
| title_full_unstemmed | Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population |
| title_short | Maternal exposure to benzophenone derivatives and their impacts on offspring's birth outcomes in a Middle Eastern population |
| title_sort | maternal exposure to benzophenone derivatives and their impacts on offspring s birth outcomes in a middle eastern population |
| url | https://doi.org/10.1038/s41598-023-35380-5 |
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