Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease
Chagas disease is an important infection in Latin America but it is also reported in non-endemic countries all over the world. Around 30% of infected patients develop chronic Chagas cardiopathy, which is responsible for most poor outcomes, mainly heart failure, arrhythmias and thromboembolic events....
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/5/2/82 |
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| author | Fernanda de Souza Nogueira Sardinha Mendes Mauro Felippe Felix Mediano Rudson Santos Silva Sergio Salles Xavier Pedro Emmanuel Alvarenga Americano do Brasil Roberto Magalhães Saraiva Alejandro Marcel Hasslocher-Moreno Andrea Silvestre de Sousa |
| author_facet | Fernanda de Souza Nogueira Sardinha Mendes Mauro Felippe Felix Mediano Rudson Santos Silva Sergio Salles Xavier Pedro Emmanuel Alvarenga Americano do Brasil Roberto Magalhães Saraiva Alejandro Marcel Hasslocher-Moreno Andrea Silvestre de Sousa |
| author_sort | Fernanda de Souza Nogueira Sardinha Mendes |
| collection | DOAJ |
| description | Chagas disease is an important infection in Latin America but it is also reported in non-endemic countries all over the world. Around 30% of infected patients develop chronic Chagas cardiopathy, which is responsible for most poor outcomes, mainly heart failure, arrhythmias and thromboembolic events. Of all thromboembolic events, stroke is the most feared, due to the high probability of evolution to death or disability. Despite its importance, the actual incidence of cardioembolic ischemic stroke in Chagas disease is not completely known. The Instituto de Pesquisa Evandro Chagas/Fundação Oswaldo Cruz (IPEC-FIOCRUZ) score aims to propose prophylaxis strategies against cardioembolic ischemic stroke in Chagas disease based on clinical risk–benefit. To date, the IPEC-FIOCRUZ score is considered the best tool to identify patients for stroke prophylaxis in Chagas disease according the Latin American guideline and Brazilian consensus. It can prevent many cardioembolic strokes that would not be predicted, by applying the current recommendations to other cardiopathies. However, the IPEC-FIOCRUZ score still requires external validation to be used in different Chagas disease populations with an appropriate study design. |
| first_indexed | 2024-03-10T19:35:42Z |
| format | Article |
| id | doaj.art-6bff223053364ac6b77673da4782aa24 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T19:35:42Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-6bff223053364ac6b77673da4782aa242023-11-20T01:45:26ZengMDPI AGTropical Medicine and Infectious Disease2414-63662020-05-01528210.3390/tropicalmed5020082Discussing the Score of Cardioembolic Ischemic Stroke in Chagas DiseaseFernanda de Souza Nogueira Sardinha Mendes0Mauro Felippe Felix Mediano1Rudson Santos Silva2Sergio Salles Xavier3Pedro Emmanuel Alvarenga Americano do Brasil4Roberto Magalhães Saraiva5Alejandro Marcel Hasslocher-Moreno6Andrea Silvestre de Sousa7Instituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilInstituto Nacional de Infectologia Evandro Chagas, Oswaldo Cruz Foundation (Fiocruz), Avenida Brasil 4365, Rio de Janeiro 21045-900, BrazilChagas disease is an important infection in Latin America but it is also reported in non-endemic countries all over the world. Around 30% of infected patients develop chronic Chagas cardiopathy, which is responsible for most poor outcomes, mainly heart failure, arrhythmias and thromboembolic events. Of all thromboembolic events, stroke is the most feared, due to the high probability of evolution to death or disability. Despite its importance, the actual incidence of cardioembolic ischemic stroke in Chagas disease is not completely known. The Instituto de Pesquisa Evandro Chagas/Fundação Oswaldo Cruz (IPEC-FIOCRUZ) score aims to propose prophylaxis strategies against cardioembolic ischemic stroke in Chagas disease based on clinical risk–benefit. To date, the IPEC-FIOCRUZ score is considered the best tool to identify patients for stroke prophylaxis in Chagas disease according the Latin American guideline and Brazilian consensus. It can prevent many cardioembolic strokes that would not be predicted, by applying the current recommendations to other cardiopathies. However, the IPEC-FIOCRUZ score still requires external validation to be used in different Chagas disease populations with an appropriate study design.https://www.mdpi.com/2414-6366/5/2/82Chagas diseasestrokerisk assessment |
| spellingShingle | Fernanda de Souza Nogueira Sardinha Mendes Mauro Felippe Felix Mediano Rudson Santos Silva Sergio Salles Xavier Pedro Emmanuel Alvarenga Americano do Brasil Roberto Magalhães Saraiva Alejandro Marcel Hasslocher-Moreno Andrea Silvestre de Sousa Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease Tropical Medicine and Infectious Disease Chagas disease stroke risk assessment |
| title | Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease |
| title_full | Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease |
| title_fullStr | Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease |
| title_full_unstemmed | Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease |
| title_short | Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease |
| title_sort | discussing the score of cardioembolic ischemic stroke in chagas disease |
| topic | Chagas disease stroke risk assessment |
| url | https://www.mdpi.com/2414-6366/5/2/82 |
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