Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America
PURPOSEDespite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. This study analyzes ALL in Latin America (LA) and recommends diagnosis, treatment, and management protocols.METHODSThe Americas Healt...
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| Format: | Article |
| Language: | English |
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American Society of Clinical Oncology
2023-05-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO.22.00292 |
| _version_ | 1797829205318172672 |
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| author | Ana Lisa Basquiera Maria Cristina Seiwald Carlos Roberto Best Aguilera Leonardo Enciso Isolda Fernandez Angela Marie Jansen Elenaide Nunes Matias Sanchez del Villar Victor I. Urbalejo Ceniceros Vanderson Rocha |
| author_facet | Ana Lisa Basquiera Maria Cristina Seiwald Carlos Roberto Best Aguilera Leonardo Enciso Isolda Fernandez Angela Marie Jansen Elenaide Nunes Matias Sanchez del Villar Victor I. Urbalejo Ceniceros Vanderson Rocha |
| author_sort | Ana Lisa Basquiera |
| collection | DOAJ |
| description | PURPOSEDespite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. This study analyzes ALL in Latin America (LA) and recommends diagnosis, treatment, and management protocols.METHODSThe Americas Health Foundation organized a panel of hematologists from Argentina, Brazil, Chile, Colombia, and Mexico to examine ALL diagnosis and therapy and produce recommendations.RESULTSLack of regional data, unequal access to diagnosis and therapy, inadequate treatment response, and uneven health care distribution complicate adult ALL management. The panel recommended diagnosis, first-line and refractory treatment, and post-transplantation maintenance. Targeted treatments, including rituximab, blinatumomab, and inotuzumab ozogamicin, are becoming available in LA and must be equitably accessed.CONCLUSIONThis review adapts global information on treating ALL to LA. Governments, the medical community, society, academia, industry, and patient advocates must work together to improve policies. |
| first_indexed | 2024-04-09T13:16:39Z |
| format | Article |
| id | doaj.art-6c0174ea76ec4fbbaa33a2112183f85b |
| institution | Directory Open Access Journal |
| issn | 2687-8941 |
| language | English |
| last_indexed | 2024-04-09T13:16:39Z |
| publishDate | 2023-05-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj.art-6c0174ea76ec4fbbaa33a2112183f85b2023-05-11T19:59:10ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412023-05-01910.1200/GO.22.00292Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin AmericaAna Lisa Basquiera0Maria Cristina Seiwald1Carlos Roberto Best Aguilera2Leonardo Enciso3Isolda Fernandez4Angela Marie Jansen5Elenaide Nunes6Matias Sanchez del Villar7Victor I. Urbalejo Ceniceros8Vanderson Rocha9Hematology and Oncology Service, Bone Marrow Transplant Program, Hospital Privado Universitario de Cordoba, Instituto Universitario de Ciencias Biomédicas de Cordoba (IUCBC), Cordoba, ArgentinaDepartment of Clinical Medicine, Hematology and Hemotherapy, University of Sao Paulo (FMUSP), Sao Paulo, BrazilConacyt National Quality Postgraduate Program, University of Guadalajara & Western General Hospital, Guadalajara, MexicoNational University of Colombia, Bogota, ColombiaDepartment of Hematology, Fundaleu, Buenos Aires, ArgentinaAmericas Health Foundation, Washington, DCHospital de Clínicas—Federal University of Parana, Parana, BrazilChief Bone Marrow Transplant Service, Department of Hematology, Clinica Alemana de Santiago, Santiago, ChileDepartment of Hematology, National Cancer Institute, Mexico City, MexicoDepartment of Clinical Medicine, Hematology and Hemotherapy, University of Sao Paulo (FMUSP), Sao Paulo, BrazilPURPOSEDespite strong induction chemotherapy response rates, only 30%-40% of patients with adult B-cell acute lymphoblastic leukemia (ALL) attain long-term remission. This study analyzes ALL in Latin America (LA) and recommends diagnosis, treatment, and management protocols.METHODSThe Americas Health Foundation organized a panel of hematologists from Argentina, Brazil, Chile, Colombia, and Mexico to examine ALL diagnosis and therapy and produce recommendations.RESULTSLack of regional data, unequal access to diagnosis and therapy, inadequate treatment response, and uneven health care distribution complicate adult ALL management. The panel recommended diagnosis, first-line and refractory treatment, and post-transplantation maintenance. Targeted treatments, including rituximab, blinatumomab, and inotuzumab ozogamicin, are becoming available in LA and must be equitably accessed.CONCLUSIONThis review adapts global information on treating ALL to LA. Governments, the medical community, society, academia, industry, and patient advocates must work together to improve policies.https://ascopubs.org/doi/10.1200/GO.22.00292 |
| spellingShingle | Ana Lisa Basquiera Maria Cristina Seiwald Carlos Roberto Best Aguilera Leonardo Enciso Isolda Fernandez Angela Marie Jansen Elenaide Nunes Matias Sanchez del Villar Victor I. Urbalejo Ceniceros Vanderson Rocha Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America JCO Global Oncology |
| title | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
| title_full | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
| title_fullStr | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
| title_full_unstemmed | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
| title_short | Expert Recommendations for the Diagnosis, Treatment, and Management of Adult B-Cell Acute Lymphoblastic Leukemia in Latin America |
| title_sort | expert recommendations for the diagnosis treatment and management of adult b cell acute lymphoblastic leukemia in latin america |
| url | https://ascopubs.org/doi/10.1200/GO.22.00292 |
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