Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease

Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of Graves' disease. Due to difficulties in previous methods for dose determination, fixed dose method of 1-131 is now considered the best practical method for 1-131 therapy in Graves&apo...

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Main Authors: Fard Esfahani A, Dabbagh Kakhki VR, Eftekhari M, Zarpak B, Saghari U, Tallahi B
Format: Article
Language:fas
Published: Tehran University of Medical Sciences 2003-09-01
Series:Tehran University Medical Journal
Subjects:
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5413.pdf&manuscript_id=5413
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author Fard Esfahani A
Dabbagh Kakhki VR
Eftekhari M
Zarpak B
Saghari U
Tallahi B
author_facet Fard Esfahani A
Dabbagh Kakhki VR
Eftekhari M
Zarpak B
Saghari U
Tallahi B
author_sort Fard Esfahani A
collection DOAJ
description Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of Graves' disease. Due to difficulties in previous methods for dose determination, fixed dose method of 1-131 is now considered the best practical method for 1-131 therapy in Graves' disease, but there is no consensus on the dose. We compared two routinely recommended fixed doses of 5 and 10 mCi for this purpose."nMaterials and Methods; In this clinical trial, 59 patients with Graves' disease referred for radioiodine therapy were randomized into two groups, one group was treated with 5 mCi of 1-131 and the other with 10 mCi. All patients were followed for two years, with 6-month intervals."nResults: Totally, among 59 patients treated with 1-131, 20 (33.9%) patients became euthyroid and 19(32.2%) became hypothyroid, while failed therapy (no response or relapse) was noticed in 20 patients (33.9%). In the group treated by 5 mCi (33 patients), 10(30.3%) were euthyroid, 6(18.2%) were hypothyroid (overall cure of ^8.5%), while 17(51.5%) remained hyperthyroid by the end of the follow-up period. From the 26 patients treated with 10 mCi, the euthyroid and hypothyroid states were observed in 10(38.5%) and 13(50%)patients, respectively (overall cure rate of 88.5%), and hyperthyroid state in 3(11.5%). No relationship was noted between the outcome and age, sex, size of the thyroid gland and thyroid uptake, but the relationship between the disease outcome and the amount of administered radioiodine was significant (P<0.003). Although the incidence rate of early hypothyroidism (by the end of 2 years) in the group treated with 5 mCi is less than those treated with 10 mCi, the incidence of failed therapy is higher in the former group. In addition, it is known that long-term hypothyroidism prevalence is not significantly different by using different doses of I-131. On the other hand, if the initial dose is so little to cure, cost and time for perfect treatment, number of office visits and morbidity due to untreated hyperthyroidism are markedly increased."nConclusion: Regarding lower rate of failed therapy with 10 mCi, and as there is no significant difference in late hypothyroidism between low doses and high doses of I-131, we concluded that 10 mci is the optimal fixed dose for treatment of Graves' disease.
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spelling doaj.art-6c01ab9be7ac4fdaa8cc6ec3b6b2fbb92022-12-22T02:19:05ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222003-09-01614300307Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' DiseaseFard Esfahani ADabbagh Kakhki VREftekhari MZarpak BSaghari UTallahi BRadioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of Graves' disease. Due to difficulties in previous methods for dose determination, fixed dose method of 1-131 is now considered the best practical method for 1-131 therapy in Graves' disease, but there is no consensus on the dose. We compared two routinely recommended fixed doses of 5 and 10 mCi for this purpose."nMaterials and Methods; In this clinical trial, 59 patients with Graves' disease referred for radioiodine therapy were randomized into two groups, one group was treated with 5 mCi of 1-131 and the other with 10 mCi. All patients were followed for two years, with 6-month intervals."nResults: Totally, among 59 patients treated with 1-131, 20 (33.9%) patients became euthyroid and 19(32.2%) became hypothyroid, while failed therapy (no response or relapse) was noticed in 20 patients (33.9%). In the group treated by 5 mCi (33 patients), 10(30.3%) were euthyroid, 6(18.2%) were hypothyroid (overall cure of ^8.5%), while 17(51.5%) remained hyperthyroid by the end of the follow-up period. From the 26 patients treated with 10 mCi, the euthyroid and hypothyroid states were observed in 10(38.5%) and 13(50%)patients, respectively (overall cure rate of 88.5%), and hyperthyroid state in 3(11.5%). No relationship was noted between the outcome and age, sex, size of the thyroid gland and thyroid uptake, but the relationship between the disease outcome and the amount of administered radioiodine was significant (P<0.003). Although the incidence rate of early hypothyroidism (by the end of 2 years) in the group treated with 5 mCi is less than those treated with 10 mCi, the incidence of failed therapy is higher in the former group. In addition, it is known that long-term hypothyroidism prevalence is not significantly different by using different doses of I-131. On the other hand, if the initial dose is so little to cure, cost and time for perfect treatment, number of office visits and morbidity due to untreated hyperthyroidism are markedly increased."nConclusion: Regarding lower rate of failed therapy with 10 mCi, and as there is no significant difference in late hypothyroidism between low doses and high doses of I-131, we concluded that 10 mci is the optimal fixed dose for treatment of Graves' disease.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5413.pdf&manuscript_id=54131-131Fixed dose therapy
spellingShingle Fard Esfahani A
Dabbagh Kakhki VR
Eftekhari M
Zarpak B
Saghari U
Tallahi B
Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease
Tehran University Medical Journal
1-131
Fixed dose therapy
title Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease
title_full Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease
title_fullStr Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease
title_full_unstemmed Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease
title_short Comparative Evaluation Of The Two Fixed Dose Methods Of Radioiodine Therapy (5mci And 10 Mci) For The Treatment Of Graves' Disease
title_sort comparative evaluation of the two fixed dose methods of radioiodine therapy 5mci and 10 mci for the treatment of graves apos disease
topic 1-131
Fixed dose therapy
url http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/5413.pdf&manuscript_id=5413
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AT eftekharim comparativeevaluationofthetwofixeddosemethodsofradioiodinetherapy5mciand10mciforthetreatmentofgravesaposdisease
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