Selective Inhibition of Heparan Sulphate and Not Chondroitin Sulphate Biosynthesis by a Small, Soluble Competitive Inhibitor

Selective Inhibition of Heparan Sulphate and Not Chondroitin Sulphate Biosynthesis by a Small, Soluble Competitive Inhibitor

The glycosaminoglycan, heparan sulphate (HS), orchestrates many developmental processes. Yet its biological role has not yet fully been elucidated. Small molecule chemical inhibitors can be used to perturb HS function and these compounds provide cheap alternatives to genetic manipulation methods. Ho...

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Bibliographic Details
Main Authors:	Marissa L. Maciej-Hulme, Eamon Dubaissi, Chun Shao, Joseph Zaia, Enrique Amaya, Sabine L. Flitsch, Catherine L. R. Merry
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	International Journal of Molecular Sciences
Subjects:	heparan sulfate azido sugar glycosaminoglycan carbohydrate biosynthesis small molecule inhibitor biorthogonal chemistry
Online Access:	https://www.mdpi.com/1422-0067/22/13/6988

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