Effects of gene polymorphisms of CYP1A1, CYP1B1, EPHX1, NQO1, and NAT2 on urinary 1-nitropyrene metabolite concentrations

Effects of gene polymorphisms of CYP1A1, CYP1B1, EPHX1, NQO1, and NAT2 on urinary 1-nitropyrene metabolite concentrations

Nitropyrene (1-NP) is a specific indicator of exposure to diesel exhaust and is partly metabolized to 1-aminopyrene (1-AP) and N-acetyl-1-aminopyrene (1-NAAP), which are excreted in urine. This study was conducted to evaluate the effects of gene polymorphisms of metabolic enzymes for 1-NP on the uri...

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Bibliographic Details
Main Authors: Jung-Kuk Yun, Bolormaa Ochirpurev, Sang-Yong Eom, Akira Toriba, Yong-Dae Kim, Heon Kim
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Heliyon
Subjects:
Diesel exhaust
1-nitropyrene
1-aminopyrene
N-acetyl-1-aminopyrene
Metabolic enzymes
Genetic polymorphism
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022014086

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