Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps—Structure-Activity-Relationship and Mechanism Studies

Chalcones are responsible for biological activity throughout fruits, vegetables, and medicinal plants in preventing and treating a variety of inflammation-related diseases. However, their structure-activity relationship (SAR) in inhibiting inflammasome activation has not been explored. We synthesize...

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Bibliographic Details
Main Authors: Wohn-Jenn Leu, Jung-Chun Chu, Jui-Ling Hsu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Wei-Jan Huang, Jih-Hwa Guh
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
chalcone
NLRP3 inflammasome
structure-activity relationship
NF-ĸB
ATP
K<sup>+</sup> efflux
Online Access:https://www.mdpi.com/1420-3049/25/24/5960

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