Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism
IntroductionForebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcriptomic mechanisms that maintain forebrain E-I balance and optimal cognition remain uncle...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1114037/full |
| _version_ | 1797895005208051712 |
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| author | Tian Tian You Cai You Cai Xin Qin Jiangang Wang Yali Wang Xin Yang |
| author_facet | Tian Tian You Cai You Cai Xin Qin Jiangang Wang Yali Wang Xin Yang |
| author_sort | Tian Tian |
| collection | DOAJ |
| description | IntroductionForebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcriptomic mechanisms that maintain forebrain E-I balance and optimal cognition remain unclear.MethodsWe used patch-clamp and RNA sequencing to investigate the patterns of neural network homeostasis with suppressing forebrain excitatory neural activity and spatial training.ResultsWe found that inhibitory transmission and receptor transcription were reduced in tamoxifen-inducible Kir2.1 conditional knock-in mice. In contrast, spatial training increased inhibitory synaptic connections and the transcription of inhibitory receptors.DiscussionOur study provides significant evidence that inhibitory systems play a critical role in the homeostatic control of the E-I balance in the forebrain during cognitive training and E-I rebalance, and we have provided insights into multiple gene candidates for cognition-related homeostasis in the forebrain. |
| first_indexed | 2024-04-10T07:19:37Z |
| format | Article |
| id | doaj.art-6c06ec3aa7c74cb287f4e3058d757e67 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-10T07:19:37Z |
| publishDate | 2023-02-01 |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-6c06ec3aa7c74cb287f4e3058d757e672023-02-24T14:33:26ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-02-011710.3389/fncel.2023.11140371114037Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanismTian Tian0You Cai1You Cai2Xin Qin3Jiangang Wang4Yali Wang5Xin Yang6Shenzhen Key Laboratory of Translational Research for Brain Diseases, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaShenzhen Key Laboratory of Translational Research for Brain Diseases, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Neurology, Shenzhen Institute of Translational Medicine, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Medicine, Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, BC, CanadaHenan International Joint Laboratory of Non-Invasive Neuromodulation, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang, ChinaHenan International Joint Laboratory of Non-Invasive Neuromodulation, Department of Physiology and Pathophysiology, Xinxiang Medical University, Xinxiang, ChinaShenzhen Key Laboratory of Translational Research for Brain Diseases, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaIntroductionForebrain neural networks are vital for cognitive functioning, and their excitatory-inhibitory (E-I) balance is governed by neural homeostasis. However, the homeostatic control strategies and transcriptomic mechanisms that maintain forebrain E-I balance and optimal cognition remain unclear.MethodsWe used patch-clamp and RNA sequencing to investigate the patterns of neural network homeostasis with suppressing forebrain excitatory neural activity and spatial training.ResultsWe found that inhibitory transmission and receptor transcription were reduced in tamoxifen-inducible Kir2.1 conditional knock-in mice. In contrast, spatial training increased inhibitory synaptic connections and the transcription of inhibitory receptors.DiscussionOur study provides significant evidence that inhibitory systems play a critical role in the homeostatic control of the E-I balance in the forebrain during cognitive training and E-I rebalance, and we have provided insights into multiple gene candidates for cognition-related homeostasis in the forebrain.https://www.frontiersin.org/articles/10.3389/fncel.2023.1114037/fullhomeostasisGABAforebraincognitionE-I balance significance statement |
| spellingShingle | Tian Tian You Cai You Cai Xin Qin Jiangang Wang Yali Wang Xin Yang Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism Frontiers in Cellular Neuroscience homeostasis GABA forebrain cognition E-I balance significance statement |
| title | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism |
| title_full | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism |
| title_fullStr | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism |
| title_full_unstemmed | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism |
| title_short | Forebrain E-I balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism |
| title_sort | forebrain e i balance controlled in cognition through coordinated inhibition and inhibitory transcriptome mechanism |
| topic | homeostasis GABA forebrain cognition E-I balance significance statement |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1114037/full |
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