Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy
Anal sac squamous cell carcinoma (SCC) is a rare tumor in dogs. Only eight cases have been described in the literature, and previous reports of treatment only describe surgery or palliative treatment with non-steroidal anti-inflammatory drugs. We report a case of a 12-year-old female neutered Labrad...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/4/3/45 |
| _version_ | 1818560276612513792 |
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| author | Antonio Giuliano Jane Dobson Sarah Mason |
| author_facet | Antonio Giuliano Jane Dobson Sarah Mason |
| author_sort | Antonio Giuliano |
| collection | DOAJ |
| description | Anal sac squamous cell carcinoma (SCC) is a rare tumor in dogs. Only eight cases have been described in the literature, and previous reports of treatment only describe surgery or palliative treatment with non-steroidal anti-inflammatory drugs. We report a case of a 12-year-old female neutered Labrador with locally advanced anal sac SCC. The dog was treated with four cycles of carboplatin 300 mg/m2 and four weekly fractions of 8.5 Gy radiation. The dog achieved a complete response, and one year later the dog is still alive and well with no evidence of tumor recurrence. Radiotherapy in combination with carboplatin chemotherapy was effective in the long-term control of this rare disease. |
| first_indexed | 2024-12-14T00:36:25Z |
| format | Article |
| id | doaj.art-6c083a19b1b74a568840db0f1bf706c8 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-12-14T00:36:25Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-6c083a19b1b74a568840db0f1bf706c82022-12-21T23:24:38ZengMDPI AGVeterinary Sciences2306-73812017-09-01434510.3390/vetsci4030045vetsci4030045Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin ChemotherapyAntonio Giuliano0Jane Dobson1Sarah Mason2Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UKDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UKDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UKAnal sac squamous cell carcinoma (SCC) is a rare tumor in dogs. Only eight cases have been described in the literature, and previous reports of treatment only describe surgery or palliative treatment with non-steroidal anti-inflammatory drugs. We report a case of a 12-year-old female neutered Labrador with locally advanced anal sac SCC. The dog was treated with four cycles of carboplatin 300 mg/m2 and four weekly fractions of 8.5 Gy radiation. The dog achieved a complete response, and one year later the dog is still alive and well with no evidence of tumor recurrence. Radiotherapy in combination with carboplatin chemotherapy was effective in the long-term control of this rare disease.https://www.mdpi.com/2306-7381/4/3/45anal sac squamous cell carcinomacarboplatinradiotherapy |
| spellingShingle | Antonio Giuliano Jane Dobson Sarah Mason Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy Veterinary Sciences anal sac squamous cell carcinoma carboplatin radiotherapy |
| title | Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy |
| title_full | Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy |
| title_fullStr | Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy |
| title_full_unstemmed | Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy |
| title_short | Complete Resolution of a Recurrent Canine Anal Sac Squamous Cell Carcinoma with Palliative Radiotherapy and Carboplatin Chemotherapy |
| title_sort | complete resolution of a recurrent canine anal sac squamous cell carcinoma with palliative radiotherapy and carboplatin chemotherapy |
| topic | anal sac squamous cell carcinoma carboplatin radiotherapy |
| url | https://www.mdpi.com/2306-7381/4/3/45 |
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