Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

Telomerase synthesizes chromosome-capping telomeric repeats using an active site in telomerase reverse transcriptase (TERT) and an integral RNA subunit template. The fundamental question of whether human telomerase catalytic activity requires cooperation across two TERT subunits remains under debate...

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Bibliographic Details
Main Authors: Robert Alexander Wu, Yavuz S Dagdas, S Tunc Yilmaz, Ahmet Yildiz, Kathleen Collins
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
fluorescence imaging
telomerase
telomeric repeat synthesis
Online Access:https://elifesciences.org/articles/08363

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