The Landscape of PDK1 in Breast Cancer
Given that 3-phosphoinositide-dependent kinase 1 (PDK1) plays a crucial role in the malignant biological behaviors of a wide range of cancers, we review the influence of PDK1 in breast cancer (BC). First, we describe the power of PDK1 in cellular behaviors and characterize the interaction networks o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/3/811 |
| _version_ | 1797488648032092160 |
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| author | Na Wang Jianjiang Fu Zhihua Li Ningni Jiang Yanhong Chen Juan Peng |
| author_facet | Na Wang Jianjiang Fu Zhihua Li Ningni Jiang Yanhong Chen Juan Peng |
| author_sort | Na Wang |
| collection | DOAJ |
| description | Given that 3-phosphoinositide-dependent kinase 1 (PDK1) plays a crucial role in the malignant biological behaviors of a wide range of cancers, we review the influence of PDK1 in breast cancer (BC). First, we describe the power of PDK1 in cellular behaviors and characterize the interaction networks of PDK1. Then, we establish the roles of PDK1 in carcinogenesis, growth and survival, metastasis, and chemoresistance in BC cells. More importantly, we sort the current preclinical or clinical trials of PDK1-targeted therapy in BC and find that, even though no selective PDK1 inhibitor is currently available for BC therapy, the combination trials of PDK1-targeted therapy and other agents have provided some benefit. Thus, there is increasing anticipation that PDK1-targeted therapy will have its space in future therapeutic approaches related to BC, and we hope the novel approaches of targeted therapy will be conducive to ameliorating the dismal prognosis of BC patients. |
| first_indexed | 2024-03-10T00:05:17Z |
| format | Article |
| id | doaj.art-6c0ae5d7323242dd9ce91b97fbafceec |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:05:17Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6c0ae5d7323242dd9ce91b97fbafceec2023-11-23T16:09:03ZengMDPI AGCancers2072-66942022-02-0114381110.3390/cancers14030811The Landscape of PDK1 in Breast CancerNa Wang0Jianjiang Fu1Zhihua Li2Ningni Jiang3Yanhong Chen4Juan Peng5Department of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaDepartment of Pathology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, ChinaGiven that 3-phosphoinositide-dependent kinase 1 (PDK1) plays a crucial role in the malignant biological behaviors of a wide range of cancers, we review the influence of PDK1 in breast cancer (BC). First, we describe the power of PDK1 in cellular behaviors and characterize the interaction networks of PDK1. Then, we establish the roles of PDK1 in carcinogenesis, growth and survival, metastasis, and chemoresistance in BC cells. More importantly, we sort the current preclinical or clinical trials of PDK1-targeted therapy in BC and find that, even though no selective PDK1 inhibitor is currently available for BC therapy, the combination trials of PDK1-targeted therapy and other agents have provided some benefit. Thus, there is increasing anticipation that PDK1-targeted therapy will have its space in future therapeutic approaches related to BC, and we hope the novel approaches of targeted therapy will be conducive to ameliorating the dismal prognosis of BC patients.https://www.mdpi.com/2072-6694/14/3/811PDK1breast cancersurvivalprognosistargeted therapy |
| spellingShingle | Na Wang Jianjiang Fu Zhihua Li Ningni Jiang Yanhong Chen Juan Peng The Landscape of PDK1 in Breast Cancer Cancers PDK1 breast cancer survival prognosis targeted therapy |
| title | The Landscape of PDK1 in Breast Cancer |
| title_full | The Landscape of PDK1 in Breast Cancer |
| title_fullStr | The Landscape of PDK1 in Breast Cancer |
| title_full_unstemmed | The Landscape of PDK1 in Breast Cancer |
| title_short | The Landscape of PDK1 in Breast Cancer |
| title_sort | landscape of pdk1 in breast cancer |
| topic | PDK1 breast cancer survival prognosis targeted therapy |
| url | https://www.mdpi.com/2072-6694/14/3/811 |
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