Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver injury worldwide. NAFLD can evolve into non-alcoholic steatohepatitis (NASH) with or without fibrosis. The objectives of this study were to determine the nutritional profile and dietary patterns of NAFLD Lebanese patients...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/14/12/2554 |
| _version_ | 1797483604381532160 |
|---|---|
| author | Nicole Fakhoury Sayegh Gessica N. H. A. Heraoui Hassan Younes Lea Nicole Sayegh Christa Boulos Raymond Sayegh |
| author_facet | Nicole Fakhoury Sayegh Gessica N. H. A. Heraoui Hassan Younes Lea Nicole Sayegh Christa Boulos Raymond Sayegh |
| author_sort | Nicole Fakhoury Sayegh |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver injury worldwide. NAFLD can evolve into non-alcoholic steatohepatitis (NASH) with or without fibrosis. The objectives of this study were to determine the nutritional profile and dietary patterns of NAFLD Lebanese patients and to report the type of diet-related to the presence of hepatic fibrosis. We hypothesized that the traditional pattern was related to a low risk of fibrosis. This cross-sectional study included 320 eligible Lebanese NAFLD patients. Three dietary patterns were identified: the Traditional diet, the High Fruit diet, and the Westernized diet. Multivariate analysis showed a significant relationship between high adherence to the traditional diet and absence of hepatic fibrosis with a decreased risk of 82%, <i>p</i> = 0.031 after adjusting for its covariables. Fruits were absent from this dietary pattern. Although our results pointed to a possible relationship between fibrosis in NAFLD patients and fruit intake, experimental studies are needed to show whether this is a causal relationship. However, the results obtained in this study may contribute to the planning of dietary interventions and recommendations and enable a better follow-up for NAFLD patients with fibrosis. |
| first_indexed | 2024-03-09T22:49:24Z |
| format | Article |
| id | doaj.art-6c0bb8345e654b18b84afa70bf988630 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:49:24Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6c0bb8345e654b18b84afa70bf9886302023-11-23T18:23:11ZengMDPI AGNutrients2072-66432022-06-011412255410.3390/nu14122554Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease PatientsNicole Fakhoury Sayegh0Gessica N. H. A. Heraoui1Hassan Younes2Lea Nicole Sayegh3Christa Boulos4Raymond Sayegh5Department of Nutrition, Faculty of Pharmacy, Saint Joseph University, Damascus Road, Riad el Solh, Beirut P.O. Box 11-5076, LebanonDepartment of Nutrition, Faculty of Pharmacy, Saint Joseph University, Damascus Road, Riad el Solh, Beirut P.O. Box 11-5076, LebanonCollege Health, équipe PANASH-ULR 7519, Institut Polytechnique UniLaSalle, 19, Rue Pierre Waguet, CEDEX, 60026 Beauvais, FranceFaculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, LebanonDepartment of Nutrition, Faculty of Pharmacy, Saint Joseph University, Damascus Road, Riad el Solh, Beirut P.O. Box 11-5076, LebanonDepartment of Gastroenterology and Hepatology, Faculty of Medicine, Saint Joseph University, Damascus Road, Riad el Solh, Beirut P.O. Box 11-5076, LebanonNon-alcoholic fatty liver disease (NAFLD) is considered the most common liver injury worldwide. NAFLD can evolve into non-alcoholic steatohepatitis (NASH) with or without fibrosis. The objectives of this study were to determine the nutritional profile and dietary patterns of NAFLD Lebanese patients and to report the type of diet-related to the presence of hepatic fibrosis. We hypothesized that the traditional pattern was related to a low risk of fibrosis. This cross-sectional study included 320 eligible Lebanese NAFLD patients. Three dietary patterns were identified: the Traditional diet, the High Fruit diet, and the Westernized diet. Multivariate analysis showed a significant relationship between high adherence to the traditional diet and absence of hepatic fibrosis with a decreased risk of 82%, <i>p</i> = 0.031 after adjusting for its covariables. Fruits were absent from this dietary pattern. Although our results pointed to a possible relationship between fibrosis in NAFLD patients and fruit intake, experimental studies are needed to show whether this is a causal relationship. However, the results obtained in this study may contribute to the planning of dietary interventions and recommendations and enable a better follow-up for NAFLD patients with fibrosis.https://www.mdpi.com/2072-6643/14/12/2554hepatic fibrosisdietary patternsthe traditional dietthe high fruit diet |
| spellingShingle | Nicole Fakhoury Sayegh Gessica N. H. A. Heraoui Hassan Younes Lea Nicole Sayegh Christa Boulos Raymond Sayegh Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients Nutrients hepatic fibrosis dietary patterns the traditional diet the high fruit diet |
| title | Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients |
| title_full | Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients |
| title_fullStr | Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients |
| title_full_unstemmed | Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients |
| title_short | Relation of Dietary Patterns and Nutritional Profile to Hepatic Fibrosis in a Sample of Lebanese Non-Alcoholic Fatty Liver Disease Patients |
| title_sort | relation of dietary patterns and nutritional profile to hepatic fibrosis in a sample of lebanese non alcoholic fatty liver disease patients |
| topic | hepatic fibrosis dietary patterns the traditional diet the high fruit diet |
| url | https://www.mdpi.com/2072-6643/14/12/2554 |
| work_keys_str_mv | AT nicolefakhourysayegh relationofdietarypatternsandnutritionalprofiletohepaticfibrosisinasampleoflebanesenonalcoholicfattyliverdiseasepatients AT gessicanhaheraoui relationofdietarypatternsandnutritionalprofiletohepaticfibrosisinasampleoflebanesenonalcoholicfattyliverdiseasepatients AT hassanyounes relationofdietarypatternsandnutritionalprofiletohepaticfibrosisinasampleoflebanesenonalcoholicfattyliverdiseasepatients AT leanicolesayegh relationofdietarypatternsandnutritionalprofiletohepaticfibrosisinasampleoflebanesenonalcoholicfattyliverdiseasepatients AT christaboulos relationofdietarypatternsandnutritionalprofiletohepaticfibrosisinasampleoflebanesenonalcoholicfattyliverdiseasepatients AT raymondsayegh relationofdietarypatternsandnutritionalprofiletohepaticfibrosisinasampleoflebanesenonalcoholicfattyliverdiseasepatients |