Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid

Mechanochemical Synthesis and Physicochemical Characterization of Previously Unreported Praziquantel Solvates with 2-Pyrrolidone and Acetic Acid

Two new solvates of the widely used anthelminthic Praziquantel (PZQ) were obtained through mechanochemical screening with different liquid additives. Specifically, 2-pyrrolidone and acetic acid gave solvates with 1:1 stoichiometry (PZQ-AA and PZQ-2P, respectively). A wide-ranging characterization of...

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Bibliographic Details
Main Authors: Debora Zanolla, Lara Gigli, Dritan Hasa, Michele R. Chierotti, Mihails Arhangelskis, Nicola Demitri, William Jones, Dario Voinovich, Beatrice Perissutti
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
praziquantel
solvates
acetic acid
2-pyrrolidone
mechanochemistry
liquid-assisted grinding
Online Access:https://www.mdpi.com/1999-4923/13/10/1606

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