Molecular Multi-Target Approach for Human Acetylcholinesterase, Butyrylcholinesterase and <i>β</i>-Secretase 1: Next Generation for Alzheimer’s Disease Treatment

Molecular Multi-Target Approach for Human Acetylcholinesterase, Butyrylcholinesterase and <i>β</i>-Secretase 1: Next Generation for Alzheimer’s Disease Treatment

Alzheimer’s Disease (AD) is a neurodegenerative condition characterized by progressive memory loss and other affected cognitive functions. Pharmacological therapy of AD relies on inhibitors of the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), offering only a palliative effect...

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Bibliographic Details
Main Authors: Géssica Oliveira Mendes, Samuel Silva da Rocha Pita, Paulo Batista de Carvalho, Michel Pires da Silva, Alex Gutterres Taranto, Franco Henrique Andrade Leite
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Pharmaceuticals
Subjects:
molecular hybrids
Alzheimer’s disease
cholinesterase
human <i>β</i>-secretase 1
molecular dynamics
Online Access:https://www.mdpi.com/1424-8247/16/6/880

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