EGCG synergizes the therapeutic effect of cisplatin and oxaliplatin through autophagic pathway in human colorectal cancer cells

EGCG synergizes the therapeutic effect of cisplatin and oxaliplatin through autophagic pathway in human colorectal cancer cells

Application of the platinum-based chemotherapy for colorectal cancer is restricted due to its severe cytotoxic effects. In this study we used synergistic strategies by combining (−)-Epigallocatechin gallate (EGCG) with cisplatin or oxaliplatin to minimize the ill effects of platinum-based therapy. M...

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Bibliographic Details
Main Authors: Fen Hu, Fei Wei, Yulei Wang, Bibo Wu, Yuan Fang, Bin Xiong
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Pharmacological Sciences
Subjects:
EGCG
Cisplatin
Oxaliplatin
Autophagic death
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315000766

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