P53 Expression in Gastric Dysplasia and carcinoma in Erbil City
Background: Alteration in the expression of p53 tumor-suppressor protein is an event that occurs frequently in human cancer, but the practical implications of this phenomenon are yet to be fully exploited. Objectives: to determine the value of p53 expression as a marker of tumor aggressiveness and t...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2011-07-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/869 |
| _version_ | 1797368521695428608 |
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| author | Bayan A. Al-Badri Gayllan Qadir Ali |
| author_facet | Bayan A. Al-Badri Gayllan Qadir Ali |
| author_sort | Bayan A. Al-Badri |
| collection | DOAJ |
| description | Background: Alteration in the expression of p53 tumor-suppressor protein is an event that occurs frequently in human cancer, but the practical implications of this phenomenon are yet to be fully exploited.
Objectives: to determine the value of p53 expression as a marker of tumor aggressiveness and the relationship between p53 over expression and clinico-pathologic variables in gastric adenocarcinoma.
Material & Methods: The expression of p53 was studied immunohisto-chemically in 10 cases with gastric dysplasia and 85 cases with gastric adenocarcinomas using formalin fixed, paraffin-embedded tissue samples. D07 a monoclonal antibody to p53 protein was used for the immunehistochemical analysis. The correlation between p53 expression in gastric dysplasia, gastric adenocarcinoma and clinicopathologic variables were analyzed.
Results: P53 positivity was found in 48.2% of gastric carcinoma cases, and 40% of gastric dysplasia. There was a significant correlation between the rate of p53 over expression and tumor grade (p = 0.015), and also with carcinomas associated with lymph node involvement (p = 0034). There was no significant association between p53 protein expression and histological type (p = 0.171). The association between p53 protein expression and the depth of tumour invasion was found to be statistically insignificant.
Conclusion: The results obtained suggest that P53 protein expression is a useful biomarker for the assessment of gastric adenocarcinoma aggressiveness. The preoperative assessment of p53 expression in gastric carcinomas can be helpful in identifying patients with higher grades and more advanced tumors. P53 immunoreactivity can predict lymph node status in patients with gastric carcinoma. |
| first_indexed | 2024-03-08T17:33:41Z |
| format | Article |
| id | doaj.art-6c0dbf1750f8479a980545e8029a72c1 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:33:41Z |
| publishDate | 2011-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-6c0dbf1750f8479a980545e8029a72c12024-01-02T13:45:20ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572011-07-0153210.32007/jfacmedbagdad.v2190-193%P53 Expression in Gastric Dysplasia and carcinoma in Erbil CityBayan A. Al-Badri0Gayllan Qadir Ali1*.Dept..of Pathology, Baghdad medical College.Health Directorate of Kirkook.Background: Alteration in the expression of p53 tumor-suppressor protein is an event that occurs frequently in human cancer, but the practical implications of this phenomenon are yet to be fully exploited. Objectives: to determine the value of p53 expression as a marker of tumor aggressiveness and the relationship between p53 over expression and clinico-pathologic variables in gastric adenocarcinoma. Material & Methods: The expression of p53 was studied immunohisto-chemically in 10 cases with gastric dysplasia and 85 cases with gastric adenocarcinomas using formalin fixed, paraffin-embedded tissue samples. D07 a monoclonal antibody to p53 protein was used for the immunehistochemical analysis. The correlation between p53 expression in gastric dysplasia, gastric adenocarcinoma and clinicopathologic variables were analyzed. Results: P53 positivity was found in 48.2% of gastric carcinoma cases, and 40% of gastric dysplasia. There was a significant correlation between the rate of p53 over expression and tumor grade (p = 0.015), and also with carcinomas associated with lymph node involvement (p = 0034). There was no significant association between p53 protein expression and histological type (p = 0.171). The association between p53 protein expression and the depth of tumour invasion was found to be statistically insignificant. Conclusion: The results obtained suggest that P53 protein expression is a useful biomarker for the assessment of gastric adenocarcinoma aggressiveness. The preoperative assessment of p53 expression in gastric carcinomas can be helpful in identifying patients with higher grades and more advanced tumors. P53 immunoreactivity can predict lymph node status in patients with gastric carcinoma.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/869P53, Gastric Dysplasia, Gastric carcinoma |
| spellingShingle | Bayan A. Al-Badri Gayllan Qadir Ali P53 Expression in Gastric Dysplasia and carcinoma in Erbil City مجلة كلية الطب P53, Gastric Dysplasia, Gastric carcinoma |
| title | P53 Expression in Gastric Dysplasia and carcinoma in Erbil City |
| title_full | P53 Expression in Gastric Dysplasia and carcinoma in Erbil City |
| title_fullStr | P53 Expression in Gastric Dysplasia and carcinoma in Erbil City |
| title_full_unstemmed | P53 Expression in Gastric Dysplasia and carcinoma in Erbil City |
| title_short | P53 Expression in Gastric Dysplasia and carcinoma in Erbil City |
| title_sort | p53 expression in gastric dysplasia and carcinoma in erbil city |
| topic | P53, Gastric Dysplasia, Gastric carcinoma |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/869 |
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